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Next Generation Sequencing (NGS) has identified genes, particularly in the WNT signaling pathway, associated with dental anomalies. MicroRNAs (miRNAs), small non\u2010coding RNA molecules, play a crucial role in post\u2010transcriptional regulation. Variants in miRNAs, such as in MIR146A, have been linked to various craniofacial pathologies. A 10\u2010year\u2010old female with a class II molar malocclusion and maxillary constriction was examined. Clinical and radiographic assessments revealed impacted cuspids (both maxillary canines and the right mandibular canine), odontoma, and root resorption. Genetic analysis showed that the patient carried two variants in MIR146A (rs2910164) and MIR182 (rs76481776). The patient exhibited skeletal anomalies including class II ponticulus posticus and sella turcica bridging. The proof\u2010of\u2010concept study incorporates relevant literature discussing the molecular basis of dental anomalies, suggesting to take into account the potential functional role of miRNAs. Previous research has associated MIR146A polymorphisms with various diseases, highlighting the need for a comprehensive understanding of genetic influences on craniofacial development. This case report presents craniofacial and dental anomalies in a patient carrying two miRNA variants. Understanding the genetic basis of dental anomalies, particularly the role of miRNAs, holds promise for future advancements in orthodontics, enabling personalized diagnostics and prognostics.<\/jats:p>","DOI":"10.1002\/ccr3.70137","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:20:25Z","timestamp":1744071625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Craniofacial and Dental Anomalies of a Patient Carrying Two\n                    <scp>MicroRNA<\/scp>\n                    Variants: A Proof\u2010Of\u2010Concept Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-5953","authenticated-orcid":false,"given":"Camilla","family":"Grenga","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, School of Dentistry \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, School of Dentistry \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Mezio","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, School of Dentistry \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Assunta","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, School of Dentistry \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Galluccio","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, School of Dentistry \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, School of Dentistry \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Giovannetti","sequence":"additional","affiliation":[{"name":"Clinical Genomics Laboratory Fondazione IRCCS Casa Sollievo Della Sofferenza, S. 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