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This case report highlights a rare instance of endometrial aspergillosis caused by <jats:italic>Aspergillus quadrilineatus<\/jats:italic> in an immunocompetent woman. A 64\u2010year\u2010old woman presented with persistent vaginal bleeding. Histopathological examination of endometrial tissue revealed septate hyphae consistent with fungal infection. Molecular analysis identified the causative agent as <jats:styled-content style=\"fixed-case\"><jats:italic>A. quadrilineatus<\/jats:italic><\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\"><jats:italic>A. quadrilineatus<\/jats:italic><\/jats:styled-content> isolate demonstrated susceptibility to various antifungal agents, including azoles and amphotericin B. This report emphasizes the need for increased awareness of fungal infections, including aspergillosis, as a potential cause of AUB. Further research is needed to enhance understanding of the epidemiology, risk factors, and clinical manifestations of endometrial aspergillosis.<\/jats:p>","DOI":"10.1002\/ccr3.70146","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T04:21:16Z","timestamp":1739420476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Unique Case of Fungal Endometritis Caused by <i>Aspergillus quadrilineatus<\/i> in an Immunocompetent Woman and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8129-0007","authenticated-orcid":false,"given":"Fatemeh Zahra","family":"Ranjbar Golafshani","sequence":"first","affiliation":[{"name":"Parasitology and medical mycology Department, Faculty of Medicine Babol University of Medical Sciences  Babol Iran"},{"name":"Infectious Diseases and Tropical Medicine Research Center Health Research Institute, Babol 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