{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:57:08Z","timestamp":1783522628150,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Aeromonas hydrophila<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>A. hydrophila<\/jats:italic><\/jats:styled-content>), a Gram\u2010negative bacterium commonly found in aquatic environments, has the capacity to be transmitted to humans through consumption of contaminated fish, water, or seafood. In this study, we present a case report concerning a 77\u2010year\u2010old female patient who experienced an acute exacerbation of chronic heart failure, subsequently developing severe septic shock due to necrotizing fasciitis caused by <jats:styled-content style=\"fixed-case\"><jats:italic>A. hydrophila<\/jats:italic><\/jats:styled-content>. Infections caused by <jats:styled-content style=\"fixed-case\"><jats:italic>A. hydrophila<\/jats:italic><\/jats:styled-content> are more prevalent during warmer months, particularly in regions characterized by dense aquaculture or the presence of natural water bodies. The excessive use of antibiotics in aquaculture has contributed to the emergence of antibiotic\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>A. hydrophila<\/jats:italic><\/jats:styled-content> strains. The proliferation of multidrug\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>A. hydrophila<\/jats:italic><\/jats:styled-content> presents a significant challenge for clinicians. In the context of atypical bacterial infections, the initial empiric therapy typically involves the use of third\u2010generation cephalosporins in conjunction with quinolone antibiotics. In the present case, the patient's successful recovery was achieved through the administration of a combination of cefoperazone\/sulbactam and levofloxacin, as determined by sensitivity testing. This case study underscores the critical importance of considering <jats:styled-content style=\"fixed-case\"><jats:italic>A. hydrophila<\/jats:italic><\/jats:styled-content> infection in patients with septic shock who present with necrotizing fasciitis.<\/jats:p>","DOI":"10.1002\/ccr3.70150","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T06:04:27Z","timestamp":1737957867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Necrotizing Fasciitis\u2010Induced Septic Shock due to <scp><i>Aeromonas hydrophila<\/i><\/scp>: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Gongjie","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit Lihuili Hospital affiliated to Ningbo University  Ningbo Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taohong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Lihuili Hospital affiliated to Ningbo University  Ningbo Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Lihuili Hospital affiliated to Ningbo University  Ningbo Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8634-4052","authenticated-orcid":false,"given":"Zhouzhou","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Lihuili Hospital affiliated to Ningbo University  Ningbo Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,26]]},"reference":[{"issue":"4","key":"e_1_2_14_2_1","first-page":"1","article-title":"A Case of Mortality Caused by Aeromonas hydrophila in Wild\u2010Caught Red\u2010Eyed Crocodile Skinks (Tribolonotus gracilis)","volume":"7","author":"Kwon J.","year":"2020","journal-title":"Veterinary Sciences"},{"issue":"1","key":"e_1_2_14_3_1","first-page":"8","article-title":"Differential Production and Secretion of Potentially Toxigenic Extracellular Proteins From Hypervirulent Aeromonas hydrophila Under Biofilm and Planktonic Culture","volume":"21","author":"Barger P. 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