{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:40:06Z","timestamp":1782222006714,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>MOSD is a rare and disabling immune\u2010mediated inflammatory Astrocytopathic disease characterized by demyelination and axonal destruction, typically involving the spinal cord and the optic nerve. Here we present a case report of a 53\u2010year\u2010old female patient who had a pertinent history of treatment for optic neuritis a few months back, currently diagnosed with Neuromyelitis Optica after she presented with a three\u2010week history of weakness of lower extremity, headache, and neuropathic pain. She was pulsed with methylprednisolone and started on azathioprine, which significantly improved her clinical condition. When patients with optic neuritis and transverse myelitis occur, a high index of suspicion for NMOSD is essential. Establishing a diagnosis based on clinical and MRI findings is crucial for initiating therapy quickly, halting more harm, and avoiding a delay in diagnosis. Our experience treating our patient shows that Azathioprine is still a practical choice in resource\u2010limited setups.<\/jats:p>","DOI":"10.1002\/ccr3.70180","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:46:41Z","timestamp":1739249201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case Report of Neuromyelitis Optica Spectrum Disorder (NMOSD) Treatment in Resource\u2010Limited Setup: An Ethiopian Experience"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0064-7236","authenticated-orcid":false,"given":"Sebhatleab T.","family":"Mulate","sequence":"first","affiliation":[{"name":"Department of Internal Medicine College of Health Science, Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6267-6642","authenticated-orcid":false,"given":"Bereket A.","family":"Molla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Health Science, Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berhanu M.","family":"Abera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Health Science, Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tseganesh M.","family":"Hailemariam","sequence":"additional","affiliation":[{"name":"College of Health Science, Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-7148","authenticated-orcid":false,"given":"Yared Z.","family":"Zewde","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Health Science, Addis Ababa University  Addis Ababa 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