{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:59:02Z","timestamp":1764255542384,"version":"3.46.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>IgG4\u2010related disease (IgG4\u2010RD) is a rare and diagnostically challenging fibroinflammatory condition characterized by diverse clinical presentations. We present the case of a 33\u2010year\u2010old male with a progressively enlarging right groin swelling over 6\u2009months. A similar episode occurred 4\u2009years prior in Nepal, with an inconclusive biopsy. Initial investigations pointed to chronic subcutaneous infectious granulomatous disease with lymphadenopathy. Following multiple missed appointments, the patient underwent excision of a soft tissue mass and lymph nodes. Histopathology revealed features consistent with IgG4\u2010RD, including follicular hyperplasia and a Castleman disease\u2010like pattern, negative for malignancy. This case underscores the diagnostic challenges of IgG4\u2010RD and the importance of considering it in the differential diagnosis of chronic lymphadenopathy. Timely follow\u2010up, histological evaluation, and awareness of IgG4\u2010RD diagnostic criteria are crucial for proper management and avoiding delayed treatment.<\/jats:p>","DOI":"10.1002\/ccr3.70224","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T03:10:55Z","timestamp":1743045055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual Presentation of an Orphan Syndrome Masquerading as Castleman Disease in a Young Adult: Diagnostic Challenges and Clinical Implications: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Mohamed Gaafar","family":"Mohamedali","sequence":"first","affiliation":[{"name":"Department of Medicine Hamad Medical Corporation, HMGH  Doha Qatar"},{"name":"Weill Cornell Medicine  Doha Qatar"},{"name":"Qatar University Medicine College  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-3375","authenticated-orcid":false,"given":"Bassem","family":"Alhariri","sequence":"additional","affiliation":[{"name":"Department of Medicine Hamad Medical Corporation, HMGH  Doha Qatar"},{"name":"Weill Cornell Medicine  Doha Qatar"},{"name":"Qatar University Medicine College  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Medical Education Department Hamad Medical Corporation  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman Osama","family":"Elhassan","sequence":"additional","affiliation":[{"name":"Medical Education Department Hamad Medical Corporation  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muayad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Medicine Hamad Medical Corporation, HMGH  Doha Qatar"},{"name":"Weill Cornell Medicine  Doha Qatar"},{"name":"Qatar University Medicine College  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afraa","family":"Fadul","sequence":"additional","affiliation":[{"name":"Department of Medicine Hamad Medical Corporation, HMGH  Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"issue":"10","key":"e_1_2_13_2_1","first-page":"13578","article-title":"Castleman Disease Variant of POEMS Syndrome Complicated With Multiple Cerebral Infarction: A Rare Case Report and Review of Literature","volume":"8","author":"Yu H.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102015\u2010214211"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13317\u2010015\u20100069\u20103"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010020\u20100500\u20107"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2022.107282"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41120"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1859710"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32832ea509"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39132"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744\u2010023\u201000593"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:54:11Z","timestamp":1764255251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ccr3.70224"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70224","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,3,27]]},"assertion":[{"value":"2024-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70224"}}