{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:21:09Z","timestamp":1764253269040,"version":"3.46.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic blood culture\u2010negative endocarditis (BCNE) presents a significant challenge for early diagnosis and treatment, leading to increased morbidity and mortality. This report presents a 30\u2010year\u2010old man with a history of BCNE who presented with an intermittent fever lasting 3\u2009months. His medical history was complex and characterized by tetralogy of Fallot (TOF), multiple cardiac surgeries, and previous positive pathological results for infection and endocarditis. A PET\/CT scan revealed hypermetabolic lesions near the prosthetic valves and aortic grafts, prompting further investigation for potential causative organisms. Subsequent serological testing and PCR confirmed the presence of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Coxiella burnetii<\/jats:italic>\n                    <\/jats:styled-content>\n                    , leading to a diagnosis of Q fever endocarditis. Treatment with doxycycline and hydroxychloroquine initiated significant improvement. Follow\u2010up after 3\u2009months showed that the patient remained stable with significant improvements in serological tests and imaging. This case underscores the necessity of considering atypical pathogens like\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. burnetii<\/jats:italic>\n                    <\/jats:styled-content>\n                    in patients with BCNE and chronic endocarditis, particularly those with complicated cardiac histories.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.70289","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T09:02:46Z","timestamp":1741338166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis of Prosthetic Endocarditis Caused by\n                    <scp>\n                      <i>Coxiella burnetii<\/i>\n                    <\/scp>\n                    Using\n                    <scp>PET<\/scp>\n                    Scan and\n                    <scp>PCR<\/scp>\n                    : A Case Report of Chronic Q Fever"],"prefix":"10.1002","volume":"13","author":[{"given":"Sara","family":"Ghaderkhani","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Topical Medicine, School of Medicine, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-0500","authenticated-orcid":false,"given":"Maryam","family":"Moradi","sequence":"additional","affiliation":[{"name":"Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Azadbakhsh kanaf gorabi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Topical Medicine, School of Medicine, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereshteh","family":"Ghiasvand","sequence":"additional","affiliation":[{"name":"Liver Transplantation Research Center, Department of Infectious Diseases, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7939-9306","authenticated-orcid":false,"given":"Farnoosh","family":"Larti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, Prehospital and Hospital Emergency Research Center, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-1737","authenticated-orcid":false,"given":"Saber","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-2378","authenticated-orcid":false,"given":"Ensiyeh","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Iranian Research Center for HIV\/AIDS, School of Medicine, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.87c.04001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.12.008"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2019-0342"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2014.11.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.3.258"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2020.02.036"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytaa512"},{"issue":"1","key":"e_1_2_12_9_1","article-title":"Q Fever Vertebral Osteomyelitis Complicating Vertebroplasty","volume":"12","author":"Dorfman K.","year":"2021","journal-title":"Rambam Maimonides Medical Journal"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.3.489"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.cme.20.1.1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-020-01787-8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11112699"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000253443.09780.0f"},{"key":"e_1_2_12_15_1","first-page":"2014","article-title":"18F\u2010FDG PET in Detecting Metastatic Infectious Disease","volume":"46","author":"Bleeker\u2010Rovers C. P.","year":"2005","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30141-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx784"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.072371"},{"issue":"4","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005521","article-title":"Seroprevalence of Q Fever Among Human and Animal in Iran; A Systematic Review and Meta\u2010Analysis","volume":"11","author":"Mobarez A. M.","year":"2017","journal-title":"PLoS Neglected Tropical Diseases"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:17:39Z","timestamp":1764253059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/ccr3.70289"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70289","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70289"}}