{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:06:00Z","timestamp":1773414360815,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Traditional medicine is becoming more popular worldwide.\n                    <jats:italic>Teucrium polium<\/jats:italic>\n                    belongs to the mint family and is a medicinal plant known for reducing blood sugar, hyperlipidemia, gastrointestinal tract issues, blood pressure, and urinary tract infections. High doses of this drug may cause liver and kidney toxicity, but this toxicity has not been thoroughly investigated. In this case report, we describe hemolysis and renal failure resulting from Arbitrary and traditional consumption of a high amount of\n                    <jats:italic>Teucreum polium<\/jats:italic>\n                    by the patient. After three cups of boiled\n                    <jats:italic>Teucreum polium<\/jats:italic>\n                    (each cup is approximately 200\u2009cc) were administered to a 45\u2010year\u2010old white woman with an underlying hypertension disease with the intention of abortion, she developed abdominal pain, weakness, lethargy, nausea, fever, chills, anorexia, and hematuria. Laboratory investigations revealed severe hemolysis (LDH\u2009=\u20093903) and a decrease in hemoglobin to 4.7\u2009mg\/dL in 12\u2009h. There was also a significant increase in the WBC, Retic count, BUN, and creatinine. A peripheral blood smear revealed +3 schistocytes and acanthosis. Viral markers, indirect coombs, and direct coombs were all negative. The primary diagnosis was acute intravascular hemolysis with renal failure. During treatment, with blood transfusion and hydration of the patient, liver and kidney function gradually improved. Due to the toxicity of medicinal plants, the unsupervised use of medicinal plants should be avoided.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.70294","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:12:24Z","timestamp":1741731144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Kidney Failure and Hemolysis Secondary to High\u2010Dose\n                    <i>Teucreum polium<\/i>\n                    (Lamiaceae): Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6360-3843","authenticated-orcid":false,"given":"Leila","family":"Gholami","sequence":"first","affiliation":[{"name":"School of Nursing Yasuj University of Medical Sciences  Yasuj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Majid","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Yasuj University of Medical Sciences  Yasuj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheida","family":"Pursusan","sequence":"additional","affiliation":[{"name":"School of Medicine Yasuj University of Medical Sciences  Yasuj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35762-3.00047-0"},{"issue":"6","key":"e_1_2_13_3_1","first-page":"354","article-title":"Hemolytic Anemia: Evaluation and Differential Diagnosis","volume":"98","author":"Phillips J.","year":"2018","journal-title":"American Family Physician"},{"issue":"1","key":"e_1_2_13_4_1","first-page":"69","article-title":"Case Report: Improving the Clinical Symptoms of a Pregnant Woman With Covid 19 With the Herbal Medicine Termino One","volume":"19","author":"Hashemi A.","year":"2022","journal-title":"Pars Journal of Medical Sciences"},{"issue":"2","key":"e_1_2_13_5_1","first-page":"229","article-title":"Study on Quantitative and Qualitative Changes in Teucrium polium L. Subsp Essential Oil Compounds. Polium at Different Phenological Stages","volume":"37","author":"Habibian S.","year":"2021","journal-title":"Iranian Journal of Medicinal and Aromatic Plants Research"},{"issue":"3","key":"e_1_2_13_6_1","first-page":"64","article-title":"Antimicrobial Activity of Methanol Extract of Citrullus colocynthis Against Antibiotic\u2010Resistant Staphylococcus Aureus","volume":"4","author":"Rezaie Keikhaie K.","year":"2018","journal-title":"Advanced Herbal Medicine"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","unstructured":"Z.MohsenipourandM.Hassanshahian \u201cAntibacterial Activity of Espand (Peganum harmala) Alcoholic Extracts Against Six Pathogenic Bacteria in Planktonic and Biofilm Forms \u201d2016.","DOI":"10.5812\/jjm.34701"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(01)00348-3"},{"issue":"1","key":"e_1_2_13_9_1","first-page":"15","article-title":"Histopathological Study of the Combination of Metformin and Garlic Juice to Attenuate Gentamicin Renal Toxicity in Rats","volume":"2","author":"Baradaran A.","year":"2013","journal-title":"Journal of Renal Injury Prevention"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-2-129"},{"key":"e_1_2_13_11_1","first-page":"89","volume-title":"Cisplatin and Renal Injury; Current Concepts","author":"Nasri H.","year":"2013"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2014.541"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105422"},{"issue":"3","key":"e_1_2_13_14_1","first-page":"80","article-title":"Hepatotoxicity of Herbal Medicinal Products","volume":"5","author":"Kotsiou A.","year":"2017","journal-title":"Journal of Medicinal Plants Studies"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2018.4052"},{"issue":"3","key":"e_1_2_13_16_1","first-page":"224","article-title":"Teucrium polium L: An Updated Review of Phytochemicals and Biological Activities","volume":"12","author":"Bahramikia S.","year":"2022","journal-title":"Avicenna Journal of Phytomedicine"},{"issue":"2","key":"e_1_2_13_17_1","first-page":"65","article-title":"The Chronic Effects of Teucrium polium on Some Blood Parameters and Histopathology of Liver and Kidney in the Rat","volume":"26","author":"Khleifat K.","year":"2002","journal-title":"Turkish Journal of Biology"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.5812\/nephropathol.12116"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1782"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2011.595864"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:17:24Z","timestamp":1764253044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/ccr3.70294"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70294","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70294"}}