{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:19:48Z","timestamp":1764253188508,"version":"3.46.0"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) that is considered life\u2010threatening and caused by dysregulation of the complement system. Here, we report a previously healthy 8\u2010year\u2010old boy who presented with features of aHUS 1\u2009week after viral symptoms during the COVID\u201019 pandemic. The patient was initially admitted for viral symptoms, pallor, edema, and urine color changes. Laboratory tests revealed anemia, thrombocytopenia, and elevated levels of creatinine and blood urea nitrogen (BUN). Despite fluid and electrolyte management, he developed pulmonary edema, necessitating hemodialysis and plasmapheresis. Genetic testing identified a homozygous pathogenic mutation in the CD46 gene, which encodes membrane cofactor protein (MCP). While initially responding to treatment, the patient experienced a relapse, requiring further interventions including eculizumab therapy. This case highlights the potential of COVID\u201019 to trigger complement\u2010mediated TMA and emphasizes the importance of prompt diagnosis, genetic assessment, and targeted complement inhibition in managing aHUS.<\/jats:p>","DOI":"10.1002\/ccr3.70308","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T22:35:01Z","timestamp":1741991701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atypical Hemolytic Uremic Syndrome Triggered by\n                    <scp>COVID<\/scp>\n                    \u201019 Infection in a Pediatric Patient With\n                    <scp>CD46<\/scp>\n                    Mutation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7217-3097","authenticated-orcid":false,"given":"Parsa","family":"Lorestani","sequence":"first","affiliation":[{"name":"Students Research Committee Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2544-548X","authenticated-orcid":false,"given":"Parisa","family":"Maleki Dana","sequence":"additional","affiliation":[{"name":"Research Center for Biochemistry and Nutrition in Metabolic Diseases Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4189-4480","authenticated-orcid":false,"given":"Mohamad Reza","family":"Tohidi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Urology and Nephrology Research Center Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"216","article-title":"Atypical Hemolytic Uremic Syndrome: Differential Diagnosis From TTP\/HUS and Management","volume":"31","author":"Yenerel M. N.","year":"2014","journal-title":"Turkish Journal of Hematology"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902814"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.10.030"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191811437"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04760512"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-020-04714-0"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.005"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:17:02Z","timestamp":1764253022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/ccr3.70308"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70308","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70308"}}