{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:21:56Z","timestamp":1790716916672,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In the majority of cases, patients with multiple myeloma (MM) generally exhibit normal or decreased blood lipid levels. However, a minority of cases demonstrate the significant role of M protein in elevated lipid levels, particularly in the close association between IgA type MM and hypertriglyceridemia and hypercholesterolemia. Here, we report a case of IgA\u2010\u03ba type MM with concurrent hyperlipidemia, wherein the patient presented with elevated lipid levels upon admission: total cholesterol of 10.44\u2009mmol\/L (normal range: 2.8\u20135.6\u2009mmol\/L) and triglycerides of 28.45\u2009mmol\/L (normal range: 0.45\u20131.70\u2009mmol\/L). The patient also had concurrent multiple myeloma and was treated with the PCD regimen along with lipid\u2010lowering measures, hydration, alkalization, liver protection, and symptomatic supportive care, and showed a significant improvement in symptoms and was discharged. The aim was to explore the relationship between IgA type MM and hyperlipidemia, and then provide guidance for clinical diagnosis and treatment.<\/jats:p>","DOI":"10.1002\/ccr3.70309","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T19:13:41Z","timestamp":1743275621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Case Report of IgA\u2010\u03ba Type Multiple Myeloma Complicated With Hyperlipidemia"],"prefix":"10.1002","volume":"13","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Luoyang Central Hospital Affiliated of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyun","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rundong","family":"Wu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Duan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3577-5861","authenticated-orcid":false,"given":"Huirui","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60493-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094462"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2436"},{"issue":"30","key":"e_1_2_11_6_1","first-page":"2140","article-title":"The Clinical Features, Chemotherapy Responses and Survival of 223 Patients With Newly Diagnosed Multiple Myeloma","volume":"88","author":"Li J.","year":"2008","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.35.337"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505992"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000535876"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520920395"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041766"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4716"},{"issue":"12","key":"e_1_2_11_13_1","first-page":"2765","article-title":"Autoimmune hyperchylomicronemia","volume":"57","author":"Nozaki S.","year":"1999","journal-title":"Nihon Rinsho"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.100552"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0849-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.009"},{"issue":"6","key":"e_1_2_11_17_1","first-page":"702","article-title":"POEMS Syndrome With IgG\u2010\u03bb\/IgA\u2010\u03ba Biclonal Gammopathy and Abnormal Serum Free Light Chain Ratio: A Case Report","volume":"45","author":"Ham J. Y.","year":"2015","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.905930"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.01.044"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06976-1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.307030"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1246-8"},{"issue":"3","key":"e_1_2_11_23_1","first-page":"OD01","article-title":"Light Chain Myeloma Induced Severe Hypertriglyceridemia","volume":"11","author":"Rahman S.","year":"2017","journal-title":"Journal of Clinical and Diagnostic Research"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:55:16Z","timestamp":1764255316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ccr3.70309"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70309","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]},"assertion":[{"value":"2024-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70309"}}