{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:19:40Z","timestamp":1764253180509,"version":"3.46.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The presence of both MDR\u2010TB and COVID\u201019 complicates diagnosis and treatment, as their symptoms can overlap, resulting in possible delays in receiving the appropriate care. This study aimed to investigate whether COVID\u201019 plays a role in the initiation or progression of latent or current tuberculosis (TB) infection, especially MDR\u2010TB, through immunosuppression or lung injury. On May 19, 2022, a retired black African 40\u2010year\u2010old woman was admitted to the emergency room. She had a history of persistent cough, fever, muscle weakness, and weight loss. Reverse transcription polymerase chain reaction (RT\u2010PCR) confirmed the presence of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), indicating a positive COVID\u201019 diagnosis. GeneXpert MTB\/RIF identified\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    <\/jats:styled-content>\n                    (Mtb) and detected rifampicin resistance, confirming MDR\u2010TB. An oral daily antituberculosis regimen consisting of 4\u2009months of kanamycin 1220\u2009mg, moxifloxacin 800\u2009mg, prothionamide 750\u2009mg, clofazimine 100\u2009mg, pyrazinamide 1200\u2009mg, high\u2010dose isoniazid (HH) 600\u2009mg, ethambutol 1200\u2009mg, and for 5\u2009months moxifloxacin 800\u2009mg, clofazimine 100\u2009mg, pyrazinamide 1200\u2009mg, and ethambutol 1200\u2009mg. She received \u2248\u20095000\u2009IU of low\u2010molecular\u2010weight heparin (80\u2009IU\/kg for her 61\u2009kg body weight) every 12\u2009h to prevent prothrombotic episodes.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.70317","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T03:41:57Z","timestamp":1742701317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual Burden of\n                    <scp>MDR<\/scp>\n                    \u2010\n                    <scp>TB<\/scp>\n                    and\n                    <scp>COVID<\/scp>\n                    \u201019 in a Previously Treated\n                    <scp>Tuberculosis<\/scp>\n                    Case: Diagnostic and Therapeutic Dilemmas"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-9601","authenticated-orcid":false,"given":"Gudisa","family":"Bereda","sequence":"first","affiliation":[{"name":"Pharmacy, All Africa Leprosy Tuberculosis and Rehabilitation Training Centre  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202411.1753.v1"},{"issue":"7","key":"e_1_2_16_3_1","article-title":"Primary Isoniazid Mono\u2010Resistant Pulmonary Tuberculosis in a COVID\u201019\u2010Positive Male: World's First Case of Its Kind in the Present Pandemic","volume":"14","author":"Yadav S.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/idr14030048"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249822"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-06527-1"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03300-2020"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202012-4333OC"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.9745\/GHSP-D-12-00004"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/venereology3040015"},{"key":"e_1_2_16_11_1","unstructured":"T.Lestari \u201cStrengthening Health Systems to Improve Tuberculosis (TB) Contact Investigation and Preventive Treatment in Mimika Indonesia \u201dhttps:\/\/ris.cdu.edu.au\/ws\/portalfiles\/portal\/94561328\/Thesis_CDU_Lestari_T.pdf."},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1738501"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268822000358"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2021.100920"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.697508"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2022.8817"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_225_21"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20\u20100851"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S433695"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010024\u201002239\u20104"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02538\u20102021"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1236099"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.11648\/j.ijmi.20210903.13"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.909011"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.21.0148"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v15.i5.853"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-18703-2.00026-8"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ado5951"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00092-3"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/20458940211015799"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691620942516"},{"key":"e_1_2_16_32_1","unstructured":"S. L.Ngema \u201cDefining the Role of High\u2010Dose Isoniazid in the Treatment of Multi\u2010Drug Resistance Tuberculosis: Isoniazid Resistant Profiling.\u201dDoctoral dissertation."},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hsr.2024.100185"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.12701\/yujm.2020.00626"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.20.0537"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:16:48Z","timestamp":1764253008000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/ccr3.70317"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70317","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2025-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70317"}}