{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:59:42Z","timestamp":1764255582804,"version":"3.46.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report the case of a 19\u2010year\u2010old woman who presented with a plethora of overlapping symptoms with complex etiology, and the final diagnosis was concurrent Wilson's disease in the background of Systemic Lupus Erythematosus and Hepatitis E infection, all of which affect similar organs and lead to a presentation with jaundice, fever, neuropsychiatric symptoms, and personality changes. In this unique case, before the manifestation o of symptoms specifically related to Wilson's disease such as bizarre behavior and initial mutism, followed by irrelevant speech, the SLE symptoms were present such as oral ulcers, alopecia, and arthralgia affecting the small joints of hands and feet along with palpitations and shortness of breath. The key clinical message is the need for thorough diagnostic evaluation, as WD can be masked or mistaken for autoimmune conditions, such as SLE. The early identification and treatment of both conditions are crucial for preventing disease progression and improving patient outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.70368","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T23:50:52Z","timestamp":1743119452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unmasking the Duo: Wilson's Disease in the Context of Lupus and Existing Hepatitis E Coinfection"],"prefix":"10.1002","volume":"13","author":[{"given":"Sana Muhammad","family":"Hussain","sequence":"first","affiliation":[{"name":"Internal Medicine Dr Ruth KM Pfau Civil Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anum","family":"Khan","sequence":"additional","affiliation":[{"name":"Internal Medicine Dr Ruth KM Pfau Civil Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Anas","sequence":"additional","affiliation":[{"name":"Internal Medicine Dr Ruth KM Pfau Civil Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarlish","family":"Khan","sequence":"additional","affiliation":[{"name":"Internal Medicine DOW University of Health Sciences  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanullah","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Internal Medicine Dr Ruth KM Pfau Civil Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-5153","authenticated-orcid":false,"given":"Md Ariful","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Public Health Atish Dipankar University of Science and Technology  Dhaka Bangladesh"},{"name":"Voice of Doctors Research School  Dhaka Bangladesh"},{"name":"Department of Orthopaedic Surgery Yan'an Hospital Affiliated to Kunming Medical University  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.24976\/Discov.Med.202436183.61"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25169034"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/children11010068"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5603\/PJNNS.a2021.0080"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011162"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-024-04713-2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1296426"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcle.2022.12.004"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010021\u201001814\u20105"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215097"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010018\u20101085\u20105"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000002298"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05463-z"},{"key":"e_1_2_12_15_1","first-page":"155","article-title":"Penicillamine and the SLE Syndrome","volume":"7","author":"Walshe J. M.","year":"1981","journal-title":"Journal of Rheumatology. Supplement"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:55:38Z","timestamp":1764255338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ccr3.70368"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70368","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,3,27]]},"assertion":[{"value":"2024-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70368"}}