{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:59:00Z","timestamp":1764255540408,"version":"3.46.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hemophilia B, an X\u2010linked recessive coagulation disorder, poses significant risks of life\u2010threatening intracranial hemorrhage (ICH). This case report details the multidisciplinary rehabilitation of a 41\u2010year\u2010old male with moderate hemophilia B (FIX activity: 3.9%) and ICH in a resource\u2010limited setting. Admitted to a high\u2010dependency unit postneurosurgical intervention, the patient received low\u2010dose prophylactic coagulation factor IX (maintained at 34.6%\u201366.2%) alongside real\u2010time coagulation monitoring. A stepwise rehabilitation protocol was implemented, including early passive joint mobilization, neuromuscular electrical stimulation, and progressive task\u2010oriented training, tailored to minimize bleeding risk. Over 7\u2009weeks, the patient achieved marked functional improvement: Activity of Daily Living score increased from 0 to 80, modified Rankin Scale improved from 5 to 3, and Fugl\u2010Meyer Assessment (FMA) rose from 0 to 60, with no secondary bleeding. This case highlights the feasibility of integrating low\u2010dose prophylaxis with early rehabilitation in developing countries, offering a cost\u2010effective model to enhance functional recovery and reduce disability in hemophilia\u2010related ICH.<\/jats:p>","DOI":"10.1002\/ccr3.70470","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T01:40:16Z","timestamp":1745286016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemophilia B With Intracranial Hemorrhage Rehabilitation in High\u2010Dependency Unit: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9442-3527","authenticated-orcid":false,"given":"Xiaoyan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010018\u20100468\u20107"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.2450\/2019.0036\u201019"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2020.02.019"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14844"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959\u2010024\u201000592\u2010w"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010020\u201003064\u20109"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201001\u2010824144"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S151812"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005083"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001358"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102516.2011.02611.x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.12104\/ji.ssn.1674\u20104748.2022.33.035"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14256"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.7664\/CHE20170914"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13111"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13764"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"issue":"7","key":"e_1_2_14_20_1","first-page":"8085","article-title":"Effect of Shujin Xiaotong Capsules Combined With Ultrashort Wave Therapy on Pain and Inflammatory Cytokines in Patients With Chronic Knee Osteoarthritis","volume":"13","author":"Guo Z.","year":"2021","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzaa054"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:54:07Z","timestamp":1764255247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ccr3.70470"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70470","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70470"}}