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The presence of one autoimmune disease can alter the immune system's balance, making the individual more susceptible to developing other autoimmune conditions. Rheumatoid arthritis and Graves' disease are two examples of autoimmune conditions that can overlap in the same patient. In this case report, we present a unique scenario of a male patient initially exhibiting symptoms suggestive of gravis' disease. The subsequent emergence of signs and symptoms of rheumatoid arthritis further complicated the situation. This overlapping presentation posed significant challenges in managing his condition and balancing the treatment regimens for both conditions while minimizing potential drug interactions and adverse effects.<\/jats:p>","DOI":"10.1002\/ccr3.70540","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:57:38Z","timestamp":1748336258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Challenging Management of Rheumatoid Arthritis Overlapping With Graves' Disease in a Young Male: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0994-1829","authenticated-orcid":false,"given":"Suaad","family":"Hamsho","sequence":"first","affiliation":[{"name":"Rheumatology Department, Faculty of Medicine Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7034-0988","authenticated-orcid":false,"given":"Ahmed","family":"Aldolly","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hama University  Hama Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8592-0898","authenticated-orcid":false,"given":"Mohammed","family":"Alaswad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hama University  Hama Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(16)30173\u20108"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-022-00293-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101387"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2023.101745"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.01.021"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.702482"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1015516"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010024\u201006888\u20106"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102529"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13103"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2007.02.007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0944"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102022\u2010223356"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24596"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112857"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2021.12.004"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00179"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010023\u201001299\u20106"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.4.422"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.142901"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102020\u2010001517"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:55:05Z","timestamp":1764251705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/ccr3.70540"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70540","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,5,27]]},"assertion":[{"value":"2025-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70540"}}