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We report an unusual case of postprandial reactive hypoglycemia in a patient with a severe esophageal stricture from corrosive agent ingestion who underwent ileocolic interposition and an antecolic Billroth\u2010II gastrojejunostomy. A 22\u2010year\u2010old male patient with a one\u2010year history of corrosive ingestion was referred to the hospital for a surgical correction of severe esophageal stricture. After the patient underwent ileocolic interposition and an antecolic Billroth\u2010II gastrojejunostomy, he experienced multiple episodes of gastroesophageal refluxsymptoms during nasogastric feeding and had onset of hypoglycemic symptoms. His plasma glucose level was 59\u2009mg\/dL. After we had intraoperatively re\u2010inserted a jejunostomy tube bypassing the ileocolic interposition, and reintroduced enteral nutrition, his hypoglycemic symptoms resolved. We performed a mixed meal tolerance test by nasogastric tube, but the results did not show postprandial hypoglycemia. Although the specific mechanism is unclear, this case suggests gastroesophageal reflux to the ileal interposition may have caused a state of exaggerated hyperinsulinemic response and rebound hypoglycemia. To the best of our knowledge, we are the first to report case of postprandial hypoglycemia after ileocolic interposition, which may have been caused by exaggerated hyperinsulinemic response due to gastroesophageal reflux to the ileal interposition. This syndrome should be considered in the patient who has had ileocolic interposition surgery and has developed postprandial hypoglycemia.<\/jats:p>","DOI":"10.1002\/ccr3.7060","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T04:09:55Z","timestamp":1679285395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postprandial hypoglycemia after ileocolic interposition and <scp>Billroth\u2010II<\/scp> gastrojejunostomy: A case report"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-5615","authenticated-orcid":false,"given":"Chanita","family":"Unhapipatpong","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Clinical Nutrition Khon Kaen Hospital  Khon Kaen 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