{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:57:00Z","timestamp":1757609820340,"version":"3.44.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Breast cancer is the most common cancer among women worldwide and the leading malignancy diagnosed during pregnancy. The estimated incidence of breast cancer in pregnancy is 6.5 cases per 100,000 live births. Management during pregnancy is guided by gestational age, aiming to achieve a safe full\u2010term delivery while minimizing adverse effects on the mother's prognosis. While the goal is to provide treatment comparable to that of nonpregnant patients, standard therapies must be adapted to ensure the safety of both the mother and the fetus. Herein we present the case of a 29\u2010year\u2010old, G3P2L2 woman in Northern Tanzania. Our patient presented at 20\u2009weeks with a 5\u2010month history of bilateral breast masses and a 2\u2010month history of back pain and lower limb weakness. The masses had developed gradually after conception and grew over time. Her breasts had been normal during her two previous pregnancies. Past medical history was notable for a new diagnosis of HIV\/AIDS which was being treated with Abacavir (ABC), Lamivudine (3TC), and Dolutegravir (DTG). A contrast CT scan of the head and neck revealed diffuse expansible lytic lesions involving skull bones, cervical spine, exposed upper ribs, and scapulae. Right axillary lymph node enlargement was also seen. A core needle biopsy was taken from both breasts, and the final histopathological report revealed an infiltrating ductal carcinoma, NST, Grade 2. After discussion by the tumor board, the decision was made to proceed with palliative management and close follow\u2010up. Unfortunately, she passed away 1\u2009week later due to respiratory complications.<\/jats:p>","DOI":"10.1002\/ccr3.70666","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T04:29:30Z","timestamp":1753849770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced Metastatic Bilateral Breast Carcinoma in a Pregnant Woman With <scp>HIV<\/scp> During the Second Trimester: A Rare Case Report and Review of the Current Literature"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9221-0452","authenticated-orcid":false,"given":"John","family":"Lugata","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"School of Medicine KCMC University  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia","family":"Makower","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Niyoyitungira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"School of Medicine KCMC University  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praygod","family":"Kitiwi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"School of Medicine KCMC University  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tecla","family":"Lyamuya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"School of Medicine KCMC University  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eusebious","family":"Maro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"School of Medicine KCMC University  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-8660","authenticated-orcid":false,"given":"Bariki","family":"Mchome","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"School of Medicine KCMC University  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-0168","authenticated-orcid":false,"given":"Alex","family":"Mremi","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"Kilimanjaro Clinical Research Institute  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2020.07.007"},{"key":"e_1_2_13_3_1","article-title":"Pregnancy\u2010Associated Breast Cancer: What Radiologists Must Know","volume":"12","author":"Soto\u2010Trujillo D.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_13_4_1","unstructured":"American Cancer Society \u201cWhat are the risks for breast cancer? \u201dwww.cancer.org."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224760"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRP.2023.154413"},{"key":"e_1_2_13_7_1","unstructured":"\u201cTanzania: mean age of childbearing 2010\u20132021 | Statista \u201dhttps:\/\/www.statista.com\/statistics\/1281252\/mean\u2010age\u2010of\u2010childbearing\u2010in\u2010tanzania\/."},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24165"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2391050083"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2008.12.007"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.2413"},{"key":"e_1_2_13_12_1","first-page":"676","article-title":"Fine Needle Aspiration of Benign and Malignant Breast Masses Associated With Pregnancy","volume":"35","author":"Novotny D. 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