{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:55:11Z","timestamp":1772164511758,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Congenital melanocytic nevi (CMN), arising from the proliferation of melanocytes, manifest at birth and are colloquially termed as bathing trunk, coat\u2010sleeve, or stocking nevi. These lesions, occurring in approximately 1 to 2% of neonates, predominantly localize over the trunk and thigh regions. Giant congenital nevi, characterized by a size exceeding 20\u2009cm, often present with pigmentation and hairiness. Herein, we present the case of a 14\u2010year\u2010old patient diagnosed with a giant congenital nevus (bathing trunk nevus) accompanied by lipomatosis, while concurrently reviewing the literature to delineate this rare association. Our investigation identified a total of six cases, comprising five females and one male. Notably, half of the cases (3\/6) exhibited multiple lipomatous lesions, with the back region emerging as the most prevalent site. In our presented case, progressive enlargement of a soft tissue mass in the right flank prompted excision, revealing a well\u2010circumscribed lipomatous lesion infiltrated diffusely by benign\u2010appearing melanocytes within fat lobules, as confirmed by immunohistochemistry. Specifically, positivity for HMB45 and S100 markers was observed. Beyond the rarity of such occurrences, our report underscores the infrequent concomitance of CMN with lipomatosis.<\/jats:p>","DOI":"10.1002\/ccr3.70700","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T04:41:12Z","timestamp":1753850472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Enlarging Mass Superimposed on a Giant Congenital Melanocytic Nevus: A Case Report and Review of Literature"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0945-4992","authenticated-orcid":false,"given":"Nabaa","family":"Al\u2010Zubaidi","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Loghman Hakim Hopsital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabertehrani","family":"Sayna","sequence":"additional","affiliation":[{"name":"Department of Pathology Danesh Pathobiology Laboratory  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra Asadi","family":"Kani","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Loghman Hakim Hopsital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-7412","authenticated-orcid":false,"given":"Mehdi","family":"Gheisari","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Loghman Hakim Hopsital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-1796","authenticated-orcid":false,"given":"Khatere","family":"Zahedi","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Loghman Hakim Hopsital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.55394"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5958\/j.2319-5886.2.4.158"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099587"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0441-4"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000231619.95263.a2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80217-4"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.07.020"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.5455\/2320-6012.ijrms20131148"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03191.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1981.tb00954.x"},{"issue":"1","key":"e_1_2_12_12_1","first-page":"154","article-title":"Giant Congenital Melanocytic Nevi: A Case Report","volume":"7","author":"Das S. K.","year":"2013","journal-title":"Journal of Clinical and Diagnostic Research"},{"issue":"6","key":"e_1_2_12_13_1","first-page":"316","article-title":"Giant Congenital Nevomelanocytic Nevus With Satellite Lesions, Vitiligo and Lipoma: A Rare Association","volume":"66","author":"Gulati R.","year":"2000","journal-title":"Indian Journal of Dermatology, Venereology and Leprology"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31743"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4172\/2376-0427.1000238"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2023.129529"},{"issue":"2","key":"e_1_2_12_17_1","first-page":"397","article-title":"Giant Hairy \u2018Bathing Trunk\u2019 Nevus With Multiple Satellite Nevi & Lipomatosis","volume":"137","author":"Thakur S. K.","year":"2013","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-228688"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7241\/ourd.2020e.7"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:12:16Z","timestamp":1756897936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/ccr3.70700"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70700","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,29]]},"assertion":[{"value":"2025-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70700"}}