{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:20:04Z","timestamp":1790472004002,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pyloric atresia (PA) is an exceptionally rare congenital cause of gastric outlet obstruction, often associated with syndromic conditions such as epidermolysis bullosa (EB). This case highlights a diagnostically challenging presentation of *non\u2010syndromic pyloric atresia* in a neonate, complicated by a moderate mid\u2010muscular ventricular septal defect (VSD), metabolic acidosis, and physiologic hydronephrosis, without any cutaneous manifestations. Initial hypotonia and respiratory irregularities diverted suspicion toward neurological or septic etiologies, delaying definitive diagnosis. Imaging, including upper gastrointestinal contrast study and echocardiography, confirmed the diagnosis of complete gastric outlet obstruction due to PA and coexisting VSD. The patient underwent successful gastro\u2010duodenostomy with resolution of symptoms and stable postoperative recovery. This case underscores the importance of maintaining a high index of suspicion for gastrointestinal obstruction in neonates with polyhydramnios and early feeding intolerance, even in the absence of classic syndromic features. Comprehensive, multidisciplinary evaluation\u2014incorporating pediatric surgery, neonatology, and cardiology\u2014is essential to address overlapping congenital anomalies and optimize outcomes. This report contributes to the limited literature on non\u2010syndromic PA with multisystem involvement.<\/jats:p>","DOI":"10.1002\/ccr3.70727","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T03:49:30Z","timestamp":1754279370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extremely Rare Neonatal Case With Pyloric Atresia, Heart Defects, Hypotonia, Jaundice, and Acidosis"],"prefix":"10.1002","volume":"13","author":[{"given":"Saja","family":"Abouodeh","sequence":"first","affiliation":[{"name":"Faculty of Medicine Palestine Polytechnic University  Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen","family":"Alshami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Palestine Polytechnic University  Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6889-2932","authenticated-orcid":false,"given":"Osama","family":"Hroub","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Palestine Polytechnic University  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hroub","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Palestine Polytechnic University  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-4980","authenticated-orcid":false,"given":"Ahmad G.","family":"Hammouri","sequence":"additional","affiliation":[{"name":"Radiology Department Al\u2010Ahli Hospital  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Shaltaf","sequence":"additional","affiliation":[{"name":"Ped Surgeon  Ramallah Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa","family":"Shihadeh","sequence":"additional","affiliation":[{"name":"Ped Surgery Fellow  Ramallah Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimatee","family":"Dawod","sequence":"additional","affiliation":[{"name":"General Surgery Resident  Ramallah Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.8762"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.10.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010007\u20101903\u20100"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114527772"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2017.02.010"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951120004576"},{"key":"e_1_2_11_8_1","first-page":"319","article-title":"Neonatal Jaundice: Phototherapy","volume":"2015","author":"Woodgate P.","year":"2015","journal-title":"BMJ Clinical Evidence"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11020279"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.10.009"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:11:29Z","timestamp":1756897889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/ccr3.70727"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70727","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70727"}}