{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:55:08Z","timestamp":1757609708669,"version":"3.44.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Japanese encephalitis (JE), a viral infection transmitted by Culex mosquitoes, primarily affects children and adolescents in endemic regions, with severe cases leading to life\u2010threatening neurological complications. We report the first documented case of JE\u2010associated quadriplegia in Nepal, involving a 19\u2010year\u2010old male presenting with high\u2010grade fever, altered sensorium, vomiting, and profound motor dysfunction. Neurological examination confirmed quadriplegia, while cerebrospinal fluid analysis revealed mildly elevated protein and glucose levels, and brain imaging was unremarkable. Diagnosis was confirmed by serum JEV\u2010specific IgM antibodies. The patient received supportive care, including hydration, antipyretics, prophylactic antibiotics, and corticosteroids, leading to significant motor function improvement over 2\u2009weeks of hospitalization. This case presents the importance of early diagnosis, timely intervention, and rehabilitation in managing severe JE manifestations and highlights the critical need for adherence to national JE vaccination schedules to prevent such debilitating outcomes in endemic areas.<\/jats:p>","DOI":"10.1002\/ccr3.70760","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T04:14:56Z","timestamp":1754453696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Japanese Encephalitis Associated With Quadriplegia: The First Reported Case of Nepal"],"prefix":"10.1002","volume":"13","author":[{"given":"Suman","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Dhangadhi Sanjeevani Hospital, Pvt. Ltd.  Dhangadhi Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3379-6565","authenticated-orcid":false,"given":"Aayush","family":"Bist","sequence":"additional","affiliation":[{"name":"Dhangadhi Sanjeevani Hospital, Pvt. Ltd.  Dhangadhi Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2009.331"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-022-01815-w"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1501.080311"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-43"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2019.332"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005866"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023071"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.4.405"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","unstructured":"A. A.Rabaan M. F.Al\u2010Subaie N. A.Al Kaabi et\u00a0al. \u201cDeciphering Clinical Predictors in Japanese Encephalitis: A Systematic Review and Meta\u2010Analysis of Effective Diagnosis and Prognosis Indicators \u201d (2024).","DOI":"10.21203\/rs.3.rs-4603955\/v1"},{"issue":"3","key":"e_1_2_12_11_1","first-page":"262","article-title":"Neurophysiological Changes in Japanese Encephalitis","volume":"50","author":"Kalita J.","year":"2002","journal-title":"Neurology India"},{"issue":"4","key":"e_1_2_12_12_1","article-title":"Management of Japanese Encephalitis: A Current Update","volume":"13","author":"Ajibowo A. 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