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While PLA has a good filling effect due to its bio\u2010stimulatory properties, it may cause complications in a certain percentage of cases. We describe three patients who developed granulomatous reactions at least 2 months after receiving subcutaneous injections of PLA\u2010based fillers. In two of the three cases, surgical removal of the infiltrate was necessary due to insufficient response to conservative treatment. Histological examination revealed unspecific chronic granulomatous inflammation of soft tissues. Based on these cases, we conclude that the causes of granuloma formation and ways to prevent it still require further research. Aesthetic specialists should carefully select patients, materials, and application techniques. Patients should be informed about the possible complications of penile girth enhancement.<\/jats:p>","DOI":"10.1002\/ccr3.70811","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T04:31:38Z","timestamp":1755664298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Foreign Body Granuloma After Polylactic Acid Filler Injection for Penile Girth Enhancement: Three Cases Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Mykola","family":"Boiko","sequence":"first","affiliation":[{"name":"Clinic \u201cAndrocentr\u201d  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5586-0337","authenticated-orcid":false,"given":"Oleksandr","family":"Boiko","sequence":"additional","affiliation":[{"name":"University Hospital of Cruces  Barakaldo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhiy","family":"Pasyechnikov","sequence":"additional","affiliation":[{"name":"O.O. 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