{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:10:03Z","timestamp":1759205403548,"version":"3.44.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Lactation\u2010associated breast cancer poses diagnostic challenges due to physiological breast changes that may mask malignancies. Triple\u2010negative breast cancer (TNBC) during lactation is rare and aggressive, requiring vigilant evaluation and treatment. This report highlights the diagnostic dilemma of recurrent cystic breast lesions during lactation, which can mimic benign conditions like galactoceles but may conceal aggressive TNBC, leading to potential delays in diagnosis despite initial conservative approaches such as aspiration. A 26\u2010year\u2010old lactating woman presented with recurrent complex cystic lesions initially mistaken for benign lactational changes. Despite multiple aspirations, the lesions enlarged, leading to surgical excision. Pathology confirmed TNBC (ER\u2212, PR\u2212, HER2\u2212, Ki\u201067 ~40%). Core needle biopsy and extended resection with sentinel lymph node biopsy confirmed grade III invasive ductal carcinoma. The patient received 8\u2009cycles of chemotherapy (4\u2009cycles of pegylated liposomal doxorubicin and cyclophosphamide, followed by 4\u2009cycles of taxane) without radiotherapy, achieving 6\u2010year recurrence\u2010free survival. Persistent complex cystic lesions during lactation require core needle biopsy to rule out malignancy. Multimodal TNBC treatment can yield favorable outcomes, including fertility preservation, as evidenced by the patient's subsequent pregnancy in 2024.<\/jats:p>","DOI":"10.1002\/ccr3.70850","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T04:01:03Z","timestamp":1757044863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Triple\u2010Negative Breast Cancer Presenting as Recurrent Cystic Lesions During Lactation: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Lixin","family":"Xue","sequence":"first","affiliation":[{"name":"Department of General Surgery, Fu Xing Hospital, the Eighth Clinical Medical College Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-6808","authenticated-orcid":false,"given":"Zhengzuo","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Fu Xing Hospital, the Eighth Clinical Medical College Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13040604"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2021.02.005"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07156-7"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61092-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09260-6"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-3448"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.11.012"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-55298-w"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121606"},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-071674","article-title":"Advances in Systemic Therapies for Triple Negative Breast Cancer","volume":"381","author":"Leon\u2010Ferre R. 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