{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:10:10Z","timestamp":1759205410338,"version":"3.44.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Trisomy 13 is a chromosomal disorder frequently associated with congenital anomalies, including polycystic kidney disease (PKD). Although the link between trisomy 13 and PKD is recognized, the timing and progression of renal cyst development remain unclear. We report a male neonate with trisomy 13 in whom we performed serial renal ultrasounds, enabling real\u2010time monitoring of PKD progression. Prenatal and immediate postnatal imaging revealed no renal abnormalities. However, progressive microcystic changes became evident by day 86, peaked around day 169, and subsequently regressed by day 434. Despite transient kidney enlargement, renal function remained stable at chronic kidney disease stage 2. This case demonstrates that regular and serial postnatal renal ultrasound is necessary to detect and manage PKD progression in trisomy 13. We recommend structured renal follow\u2010up to enable early intervention and improve clinical care in these patients.<\/jats:p>","DOI":"10.1002\/ccr3.70851","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T04:13:02Z","timestamp":1757045582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Longitudinal Case Study of Renal Cyst Progression and Regression in Trisomy 13"],"prefix":"10.1002","volume":"13","author":[{"given":"Fumiko","family":"Yamabe","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ohta Nishinouchi Hospital  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ohta Nishinouchi Hospital  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Haneda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ohta Nishinouchi Hospital  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Namai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ohta Nishinouchi Hospital  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3123-7444","authenticated-orcid":false,"given":"Yutaka","family":"Harita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62133"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37495"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.63710"},{"issue":"4","key":"e_1_2_12_5_1","first-page":"215","article-title":"Renal and Urinary Tract Abnormalities Associated With Chromosome Aberrations","volume":"8","author":"Barakat A. Y.","year":"1987","journal-title":"International Journal of Pediatric Nephrology"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iju5.12692"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00279026"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.9819"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.40350"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/875647939200800506"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010013\u20100856\u2010y"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.46377"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-43596-0_32"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010020\u201004480\u2010z"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010001\u20100624\u20100"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/children11040392"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.5.7717240"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:54:26Z","timestamp":1759204466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ccr3.70851"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70851","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70851"}}