{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:50:33Z","timestamp":1764175833896,"version":"3.44.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Vaccine\u2010induced thrombotic thrombocytopenia (VITT) has been linked to vector\u2010based vaccines, but only four cases following whole\u2010virus vaccines (Sinopharm) have been reported, as far as we are aware. This systematic review aimed to compile the clinical and laboratory results of VITT development after Sinopharm vaccination. We searched PubMed, ScienceDirect, and Google Scholar using pertinent keywords. The Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines were followed when conducting the search. Inclusion criteria were human case studies, published in English, and freely available in full text. Of the 256 studies initially identified, 4 (1.56%) were analyzed. Mean age was 55.5\u2009years (range: 18\u201385). There were <jats:italic>3 males<\/jats:italic> and <jats:italic>1 female<\/jats:italic> as per gender distribution. The most common symptom reported was sudden and extreme pain in the lower extremity (<jats:italic>n<\/jats:italic>\u2009=\u20092). The mean duration from the time of vaccination to admission was 7\u2009days, and the average platelet count was 54.38 X 10<jats:sup>9<\/jats:sup> \/L. All (<jats:italic>n<\/jats:italic>\u2009=\u20094) cases had thrombocytopenia. VITT was definitively diagnosed according to ASH Criteria for VITT in 2 case reports. VITT adapted 4Ts scoring system showed high probability (8) in all (<jats:italic>n<\/jats:italic>\u2009=\u20094) cases. Intravenous immunoglobin (IVIG) was administered in 3 VITT patients, and all patients (<jats:italic>n<\/jats:italic>\u2009=\u20094) have successfully recovered. Early recognition and timely treatment improve patient prognosis.<\/jats:p>","DOI":"10.1002\/ccr3.70873","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T07:00:56Z","timestamp":1757487656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vaccine Induced Immune Thrombotic Thrombocytopenia After Sinopharm Vaccination: A Systematic Review of Case Reports"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-0300","authenticated-orcid":false,"given":"Shafi","family":"Rehman","sequence":"first","affiliation":[{"name":"Department of Histopathology, Institute of Pathology and Diagnostic Medicine Khyber Medical University  Peshawar Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnoor","family":"Sukaina","sequence":"additional","affiliation":[{"name":"Karachi Medical and Dental College  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1817-7800","authenticated-orcid":false,"given":"Hasibullah","family":"Aminpoor","sequence":"additional","affiliation":[{"name":"Kabul University of Medical Sciences \u201cAbu Ali Ibn Sina\u201d  Kabul Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sissmol","family":"Davis","sequence":"additional","affiliation":[{"name":"JJM Medical College  Davangere India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna Bint I","family":"Munir","sequence":"additional","affiliation":[{"name":"Boston University  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-3849","authenticated-orcid":false,"given":"Hasiba","family":"Karimi","sequence":"additional","affiliation":[{"name":"Bezmialem Vakif University, Faculty of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe5938"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20\u20106841"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2021.04.003"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117607"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104882"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104840"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.15543"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(20)30831\u20108"},{"issue":"3","key":"e_1_2_15_10_1","first-page":"218","article-title":"Vaccination and Thrombotic Thrombocytopenic Purpura","volume":"37","author":"Yavasoglu I.","year":"2020","journal-title":"Turkish Journal of Haematology"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5861.303-a"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000058"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12160"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00063-010-1107-6"},{"issue":"10","key":"e_1_2_15_15_1","first-page":"587","article-title":"Thrombotic Thrombocytopenic Purpura Following Influenza Vaccination\u2014A Brief Case Report","volume":"62","author":"Ramakrishnan N.","year":"1998","journal-title":"Connecticut Medicine"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2022.2036556"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.22551\/2022.37.0904.10222"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010023\u201004086\u20107"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12750"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1717078"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.04.006"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2106315"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13813"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104840"},{"key":"e_1_2_15_25_1","doi-asserted-by":"crossref","unstructured":"K. R.McCrae \u201cThrombotic Thrombocytopenia due to SARS\u2010CoV\u20102 Vaccination \u201dCleveland Clinic Journal of Medicine ahead of print May 6 2021 https:\/\/doi.org\/10.3949\/ccjm.88a.ccc078.","DOI":"10.3949\/ccjm.88a.ccc078"},{"key":"e_1_2_15_26_1","unstructured":"COVID\u201019 Resources \u201cHelping Hematologists Conquer Blood Diseases Worldwide \u201dhttps:\/\/www.hematology.org\/covid\u201019\/vaccine\u2010induced\u2010immune\u2010thrombotic\u2010thrombocytopenia."},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010022\u201003516\u20104"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.035564"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2105385"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117085"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-324653"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102800"},{"issue":"1620","key":"e_1_2_15_33_1","first-page":"41","article-title":"FDA Authorizes Johnson & Johnson COVID\u201019 Vaccine","volume":"63","author":"Orders M.","year":"2021","journal-title":"Medical Letter on Drugs and Therapeutics"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:54:21Z","timestamp":1759204461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ccr3.70873"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70873","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2024-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70873"}}