{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:35:30Z","timestamp":1788820530256,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Brucellosis is a bacterial infection with a wide spectrum of clinical manifestations, yet endocrine complications such as primary hypogonadism and gynecomastia are exceedingly rare. We present the case of a 60\u2010year\u2010old male who was treated for brucellosis and, several weeks after discharge, developed unilateral enlargement of the left breast. Laboratory evaluation revealed significantly elevated gonadotropins (FSH and LH) with markedly decreased serum testosterone levels, indicating primary testicular failure. Sonographic imaging confirmed gynecomastia with a flame\u2010shaped, irregular mass. This case highlights a rare hormonal sequela of brucellosis and emphasizes the importance of endocrine evaluation in patients who present with atypical manifestations following systemic infections.<\/jats:p>","DOI":"10.1002\/ccr3.70880","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T04:42:46Z","timestamp":1757392966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unilateral Gynecomastia and Primary Hypogonadism Following Brucellosis Infection: A Rare Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7515-2186","authenticated-orcid":false,"given":"Yaghoub","family":"Safdari","sequence":"first","affiliation":[{"name":"Golestan Research Center of Gastroenterology and Hepatology Golestan University of Medical Sciences  Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1136674"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050570"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001929"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.03090-14"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.71.6.511"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901154"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/endocrines4030046"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.19.1542"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/324489"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:56:34Z","timestamp":1759204594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ccr3.70880"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70880","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70880"}}