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The case demonstrates the challenges in treating a chylothorax, both in terms of appropriate drainage and the necessity to maintain a low\u2010fat diet. The case also presented challenges in treating histoplasmosis, both in terms of renal effects of amphotericin B and the effect of a low\u2010fat diet on an oral antifungal agent. Although infection may be controlled with appropriate antifungal agents, the underlying hematologic malignancy must be controlled in order to successfully treat the patient.<\/jats:p>","DOI":"10.1002\/ccr3.70886","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T04:20:52Z","timestamp":1757650852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphoma Induced Chylothorax Complicated by Disseminated Histoplasmosis and Esophagopericardial Fistula"],"prefix":"10.1002","volume":"13","author":[{"given":"Bo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicine Corewell Health Southwest  Saint Joseph Michigan USA"},{"name":"Osteopathic Medical Specialties Michigan State University College of Osteopathic Medicine  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Aleksoniene","sequence":"additional","affiliation":[{"name":"Department of Medicine Corewell Health Southwest  Saint Joseph Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapna R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Osteopathic Medical Specialties Michigan State University College of Osteopathic Medicine  East Lansing Michigan USA"},{"name":"Division of Hematology and Oncology Bronson Methodist Medical Center  Battle Creek Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick C.","family":"McKillion","sequence":"additional","affiliation":[{"name":"Osteopathic Medical Specialties Michigan State University College of Osteopathic Medicine  East Lansing Michigan USA"},{"name":"Division of Critical Care Medicine Evangelical Community Hospital  Lewisburg Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0769-2372","authenticated-orcid":false,"given":"Michael S.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine Corewell Health Southwest  Saint Joseph Michigan USA"},{"name":"Osteopathic Medical Specialties Michigan State University College of Osteopathic Medicine  East Lansing Michigan USA"},{"name":"Department of Medicine Central Michigan University School of Medicine  Saginaw Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/80.7.867"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.2.586"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010015\u20104822\u20107"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2017.07.13"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454\u2010200003000\u201000022"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01964063"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.supplement_1.s19"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00027\u201006"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792\u2010198"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.6.1715"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1966.94.2.225"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmx021"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109149(76)90504\u2010x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792\u2010198"},{"issue":"3","key":"e_1_2_13_16_1","first-page":"195","article-title":"Neoplasms Metastatic to the Heart: Review of 3314 Consecutive Autopsies","volume":"3","author":"Abraham K. 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