{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:16Z","timestamp":1786977376763,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To present a patient with xerophthalmia and night blindness secondary to vitamin A deficiency following rapid weight loss. A 34\u2010year\u2010old man presented with decreased night vision, foreign body sensation, and eye dryness. He reported a rapid intentional weight loss of approximately 34\u2009kg over the past 4\u2009months through a restricted diet. Slit lamp examination revealed severe dry eye and a foamy appearance of the bulbar conjunctiva in both eyes. Retinal inner atrophy was evident on macular optical coherence tomography imaging. This case highlights critical considerations for clinical practice, particularly in managing patients experiencing rapid weight loss. It emphasizes the importance of thorough nutritional assessments in individuals undergoing significant weight changes, whether due to intentional dieting, bariatric surgery, or illness. Early identification of at\u2010risk individuals facilitates timely intervention, including dietary counseling, supplementation, and, if necessary, referral to specialists in nutrition or gastroenterology.<\/jats:p>","DOI":"10.1002\/ccr3.70896","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:53:53Z","timestamp":1758084833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Xerophthalmia and Nyctalopia as Presenting Signs of Vitamin A Deficiency in a Patient With Rapid Intentional Weight Loss: A Case Report and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"given":"Nasser","family":"Shoeibi","sequence":"first","affiliation":[{"name":"Eye Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-3831","authenticated-orcid":false,"given":"Sahel","family":"Khazaei","sequence":"additional","affiliation":[{"name":"Eye Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8680-5560","authenticated-orcid":false,"given":"Mehrdad","family":"Motamed Shariati","sequence":"additional","affiliation":[{"name":"Eye Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"issue":"5","key":"e_1_2_13_2_1","first-page":"70","article-title":"Obesity Surgery: Weight Loss, Metabolic Changes, Oncological Effects, and Follow\u2010Up","volume":"119","author":"Fink J.","year":"2022","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514847"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01609-8"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-082018-124228"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-464-3_13"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111275"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/bari.2021.0024"},{"key":"e_1_2_13_9_1","article-title":"Vitamin A Deficiency Due to Chronic Malabsorption: An Ophthalmic Manifestation of a Systemic Condition","author":"Cheshire J.","year":"2017","journal-title":"BMJ Case Reports"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-209413"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485235"},{"issue":"2","key":"e_1_2_13_12_1","first-page":"295","article-title":"Bilateral Keratomalacia Secondary to Diet Induced Vitamin A Deficiency in an Ethiopian Young Woman: A Case Report","volume":"29","author":"Daba K. 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L.","year":"2004","journal-title":"Comparative Quantification of Health Risks"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1160362"},{"key":"e_1_2_13_29_1","unstructured":"Organization WH \u201cGlobal Prevalence of Vitamin A Deficiency in Populations at Risk 1995\u20102005: WHO Global Database on Vitamin A Deficiency \u201d(2009)."},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-200010000-00007"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-020-00224-1"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-013-9403-0"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:55:57Z","timestamp":1759204557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ccr3.70896"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70896","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2024-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70896"}}