{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:10:14Z","timestamp":1759205414428,"version":"3.44.0"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Primary choriocarcinoma in males is an uncommon and aggressive subtype of germ cell tumors characterized by an early rise in human chorionic gonadotropin (hCG). While testicular cancers are the most common type of solid cancers among young males, almost half of the primary choriocarcinomas diagnosed have metastasized to lymph nodes, lungs, or liver at the time of presentation. Here we present two cases describing two middle\u2010aged men diagnosed with advanced malignancy of primary choriocarcinoma.<\/jats:p>","DOI":"10.1002\/ccr3.70903","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:34:28Z","timestamp":1758522868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Choriocarcinoma in Two Male Patients: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Abraam","family":"Rezkalla","sequence":"first","affiliation":[{"name":"Internal Medicine Resident Saint Joseph University Medical Center  Paterson New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6539-0417","authenticated-orcid":false,"given":"Islam","family":"Rajab","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident Saint Joseph University Medical Center  Paterson New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagihan","family":"Orhun","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident Saint Joseph University Medical Center  Paterson New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1323-2682","authenticated-orcid":false,"given":"Sarah","family":"Saife","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences An\u2010Najah National University  Nablus Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Rjoub","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Palestine Polytechnic University  Hebron Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,21]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.1066"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S175948"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00218"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2020.02.05"},{"issue":"11","key":"e_1_2_15_6_1","article-title":"A Rare Case of an Aggressive Mixed Germ Cell Tumor Following Testicular Torsion","volume":"16","author":"McGrath J.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-501"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb01423.x"},{"key":"e_1_2_15_9_1","unstructured":"\u201c(PDF) Testicular Choriocarcinoma With Inexplicably High Beta\u2010Human Chorionic Gonadotropin and Renal Metastases [Internet] \u201d (2025) https:\/\/www.researchgate.net\/publication\/349498805_Testicular_Choriocarcinoma_with_Inexplicably_High_Beta\u2010human_Chorionic_Gonadotropin_and_Renal_Metastases."},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v8.i21.5334"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:55:03Z","timestamp":1759204503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ccr3.70903"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70903","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70903"}}