{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:58:11Z","timestamp":1790881091628,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Guillain\u2010Barr\u00e9 Syndrome (GBS) is an immune\u2010mediated disorder affecting the peripheral nerves and nerve roots, potentially leading to severe complications such as respiratory failure and autonomic dysfunction. It is commonly preceded by gastrointestinal or respiratory infections, with various bacterial and viral pathogens identified as potential triggers. However, GBS associated with parasitic infections, such as malaria, is a rare occurrence in the medical literature. We present the case of an 18\u2010year\u2010old male who developed progressive bilateral lower extremity weakness, eventually involving the upper extremities over 1\u2009week. His symptoms were accompanied by voice changes, facial drooping, difficulty swallowing, and high\u2010grade fever. On physical examination, he exhibited fluctuating vital signs and flaccid weakness with bulbar involvement. Cerebrospinal fluid (CSF) analysis revealed an elevated protein level of 172\u2009mg\/dL with no cells. Nerve conduction studies confirmed the acute motor and sensory axonal neuropathy (AMSAN) variant of GBS. A peripheral blood film was positive for the trophozoite stage of <jats:italic>Plasmodium falciparum<\/jats:italic>. The patient was managed with intravenous artesunate and supportive care. The weakness stabilized around day 14. He showed significant improvement in cranial nerve function and upper extremity strength at 1\u2009month and was able to walk with minimal support at 2\u2009months. This case report highlights the rare occurrence of GBS after <jats:italic>Plasmodium falciparum<\/jats:italic> infection, emphasizing the importance of early diagnosis to prevent serious complications. By adding to the limited existing literature, it aims to raise awareness and encourage further research on the condition and its management.<\/jats:p>","DOI":"10.1002\/ccr3.70932","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T03:45:34Z","timestamp":1758599134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Guillain\u2010Barr\u00e9 Syndrome Following Falciparum Malaria in an 18\u2010Year Male Adolescent: A Rare Case Report and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3095-6138","authenticated-orcid":false,"given":"Gobezu Assefa","family":"Getahun","sequence":"first","affiliation":[{"name":"Gambella Town Primary Hospital  Gambella Ethiopia"},{"name":"Mekelle University, College of Health Sciences  Mekelle Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-9362","authenticated-orcid":false,"given":"Gashaw","family":"Arega","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miftah kemal","family":"jemal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jimma Institute of Health  Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biruk Getachew","family":"Woldie","sequence":"additional","affiliation":[{"name":"Mekelle University, College of Health Sciences  Mekelle Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-9695","authenticated-orcid":false,"given":"Esayas Kebede","family":"Gudina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jimma Institute of Health  Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214222"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"e_1_2_13_4_1","volume-title":"Guillain\u2010Barre Syndrome: From Diagnosis to Recovery","author":"Steinberg J. 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K.","year":"2013","journal-title":"Gastroenterology and Hepatology (N Y)"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-018-0847-3"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027989"},{"issue":"6","key":"e_1_2_13_19_1","first-page":"228","article-title":"Acute Hepatitis B Presenting as Guillain\u2010Barr\u00e9 Syndrome","volume":"22","author":"Ray G.","year":"2003","journal-title":"Indian Journal of Gastroenterology"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:56:17Z","timestamp":1759204577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ccr3.70932"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70932","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70932"}}