{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:11:20Z","timestamp":1790241080155,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Managing necrotic immature permanent teeth with an open apex presents a treatment challenge. Regenerative endodontic procedures have emerged as biologically based approaches for these cases, suggesting an alternative to conventional apexification. This report describes successful revascularization of an immature mandibular second premolar with a chronic apical abscess. Following canal disinfection with NaOCl irrigation and applying a calcium hydroxide as an intracanal medicament, a scaffold was created by inducing a blood clot within the canal. During follow\u2010up sessions, the tooth remained asymptomatic and clinically functional. Radiographic evidence demonstrated ongoing apical root development with increases in both root length and dentinal\u2010wall thickness, along with signs of apical closure. The treatment outcome supports the premise that conservative pulp revascularization can promote complete root maturation by preserving the vitality of dental pulp stem cells and providing a conducive environment for pulp regeneration.<\/jats:p>","DOI":"10.1002\/ccr3.70941","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:10:43Z","timestamp":1758719443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Regenerative Endodontic Treatment in an Immature Permanent Tooth With Necrotic Pulp and Periradicular Lesion"],"prefix":"10.1002","volume":"13","author":[{"given":"Mamak","family":"Adel","sequence":"first","affiliation":[{"name":"Department of Endodontics, Dental Caries Prevention Research Center Qazvin University of Medical Sciences  Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-6560","authenticated-orcid":false,"given":"Zohreh","family":"Asgari","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry Qazvin University of Medical Sciences  Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","first-page":"261","article-title":"Sealing Ability of Mineral Trioxide Aggregate and Calcium\u2010Enriched Mixture Cement as Apical Barriers With Different Obturation Techniques","volume":"9","author":"Tabrizizade M.","year":"2014","journal-title":"Iranian Endodontic Journal"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"79","article-title":"Apexification in Non\u2010Vital Teeth With Immature Roots: Report of Two Cases","volume":"10","author":"Silva R. 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