{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:09:57Z","timestamp":1790240997266,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Factor XIII deficiency is a very rare bleeding disorder that can cause serious bleeding problems, especially in infants. We describe a 5\u2010month\u2010old girl who came in with a rapidly increasing head size and a bulging fontanelle. She had no fever or injury. A CT scan showed bleeding in the right side of her brain and hydrocephalus. Her factor XIII level was low, about 25%, while other clotting factors were normal. Her older brother had the same condition and unfortunately died at 9\u2009months due to similar brain bleeding and infection. She was treated with plasma products to replace the missing factor, antibiotics, and seizure medications. After treatment, her condition improved and she was discharged with plans for close follow\u2010up. This case shows how factor XIII deficiency can lead to life\u2010threatening bleeding and hydrocephalus. Early diagnosis and treatment are crucial, and knowing the family history was important here. She will need ongoing monitoring to catch any future bleeding or complications early.<\/jats:p>","DOI":"10.1002\/ccr3.70962","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T03:59:41Z","timestamp":1759895981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factor XIII Deficiency: A Rare Cause of Hydrocephalus in Infancy"],"prefix":"10.1002","volume":"13","author":[{"given":"Ahmed","family":"Alali","sequence":"first","affiliation":[{"name":"Faculty of Medicine Mansoura University  Mansura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thkra","family":"Meshal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Palestine Polytechnic University  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa","family":"Alali","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Sciences Arabian Gulf University  Manama Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hamed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Mansoura University  Mansura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"Ali","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Mansoura University  Mansura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1852-6819","authenticated-orcid":false,"given":"Kareem","family":"lbraheem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Palestine Polytechnic University  Hebron Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Factor XIII Deficiency","author":"National Hemophilia Foundation","year":"2024"},{"key":"e_1_2_11_3_1","volume-title":"GeneReviews [Internet]","author":"Makris M.","year":"2023"},{"key":"e_1_2_11_4_1","volume-title":"Factor XIII Deficiency","author":"National Organization for Rare Disorders","year":"2020"},{"key":"e_1_2_11_5_1","volume-title":"Hydrocephalus","author":"Cleveland Clinic","year":"2023"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102018\u2010228682"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010013\u20101918\u20107"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101395350"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010013\u20101918\u20107"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.70962","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.70962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:50:53Z","timestamp":1790239853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.70962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ccr3.70962"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.70962","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70962"}}