{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:09:30Z","timestamp":1790240970788,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Brain metastases from ovarian carcinoma are a rare occurrence, with an incidence rate ranging from 0.49% to 6.1% of cases. These metastases are often associated with a poor prognosis, with a median survival time ranging from 2 to 10\u2009months following diagnosis. Several factors influence the prognosis, including the patient's age, overall performance status, the extent of extracranial disease, and the presence of multiple brain metastases. We describe the case of a 52\u2010year\u2010old woman with a history of stage III ovarian carcinoma diagnosed and treated in 2014. After a decade of remission, she presented with neurological symptoms in 2024, including headaches, seizures, and right\u2010sided weakness. Imaging revealed two separate brain lesions in the left parietal lobe and right cerebellar hemisphere. Both lesions were treated with hypofractionated stereotactic radiotherapy (SRT), delivering 27\u2009Gy in three sessions and 30\u2009Gy in five sessions, respectively. The treatment plan was briefly paused due to intracranial pressure but was successfully completed after symptom management with corticosteroids and mannitol. Post\u2010treatment, the patient experienced symptomatic relief, and adjuvant chemotherapy with Temozolomide was initiated. Hypofractionated SRT is a viable option for managing brain metastases from ovarian carcinoma, but individualized care and multidisciplinary approaches remain essential to address complications and improve outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.70994","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T12:55:37Z","timestamp":1758718537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Silent Threat: Delayed Brain Metastasis After Successful Ovarian Cancer Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Fatema Hashem","family":"Rupa","sequence":"first","affiliation":[{"name":"General of Health Services (DGHS)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9142-9176","authenticated-orcid":false,"given":"Mohammad Ashraful","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Public Health North South University  Dhaka Bangladesh"},{"name":"Public Health Promotion and Development Society (PPDS)  Dhaka Bangladesh"},{"name":"Department of Clinical Trials London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30676"},{"key":"e_1_2_11_3_1","unstructured":"Ovarian Cancer Key Stats* \u201cWorld Ovarian Cancer Coalition \u201daccessed January 26 2025 https:\/\/worldovariancancercoalition.org\/about\u2010ovarian\u2010cancer\/key\u2010stats\/."},{"key":"e_1_2_11_4_1","unstructured":"Services D of H& H \u201cOvarian Cancer \u201daccessed January 26 2025 http:\/\/www.betterhealth.vic.gov.au\/health\/conditionsandtreatments\/ovarian\u2010cancer."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081044"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082156"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.05.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.41102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2020.07.015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.48.57"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010023\u201002389\u2010z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ng.1700066"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2024.101444"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.334516.119"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102017"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.36000\/HBT.OH.2023.17.120"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1372077"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102023\u2010004980"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011239"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2024.35.e104"}],"container-title":["Clinical 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