{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:11:37Z","timestamp":1790241097228,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lung cancer presenting with miliary lung metastases on chest computed tomography is associated with poor prognosis. Recent studies indicate that non\u2010small cell lung cancer harboring driver gene mutations, including rearranged during transfection (\n                    <jats:italic>RET)<\/jats:italic>\n                    fusions, can manifest with miliary lung metastases. However, the efficacy of molecularly targeted therapies in\n                    <jats:italic>RET<\/jats:italic>\n                    fusion\u2010positive non\u2010small cell lung cancer with miliary dissemination remains unknown. Here, we report a case of a 45\u2010year\u2010old man with a right lower lobe lung nodule, bilateral miliary intrapulmonary metastases, extensive lymphadenopathy, and metastases to the left adrenal gland, liver, and multiple bones. Transbronchial needle aspiration confirmed lung adenocarcinoma, with\n                    <jats:italic>RET<\/jats:italic>\n                    fusion detected via gene panel testing. Treatment with selpercatinib resulted in a sustained partial response for over one year, providing the first clinical evidence supporting this targeted therapy in\n                    <jats:italic>RET<\/jats:italic>\n                    fusion\u2010positive lung adenocarcinoma with miliary metastases.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71011","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:21:10Z","timestamp":1759566070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First Report of\n                    <scp>\n                      <i>RET<\/i>\n                    <\/scp>\n                    Fusion\u2010Positive Lung Adenocarcinoma With Miliary Intrapulmonary Metastases Responsive to Selpercatinib: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Soichi","family":"Iwanaka","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Mie Chuo Medical Center  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1688-1602","authenticated-orcid":false,"given":"Tadashi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Mie Chuo Medical Center  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Mie Chuo Medical Center  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kuru","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Mie Chuo Medical Center  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Sakakura","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Mie Chuo Medical Center  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina N.","family":"D'Alessandro\u2010Gabazza","sequence":"additional","affiliation":[{"name":"Department of Immunology Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Yasuma","sequence":"additional","affiliation":[{"name":"Department of Immunology Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5748-1499","authenticated-orcid":false,"given":"Esteban C.","family":"Gabazza","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"},{"name":"Department of Immunology Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Mie Chuo Medical Center  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Ibata","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Mie Chuo Medical Center  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Mie University Faculty and Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mdr.2002.127634"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.232558"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.105986"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.3.948"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2016.09.003"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00006912"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(99)91088-7"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.04.28"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.15003"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2020.2040"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S300229"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112748"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071093"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.11.021"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2005653"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00541-1"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00393"},{"key":"e_1_2_14_19_1","first-page":"75","article-title":"LIBRETTO\u2010431: Confirming the Superiority of Selpercatinib to Chemotherapy and the Lack of Efficacy of Immune Checkpoint Inhibitors in Advanced RET Fusion\u2010Positive (RET+) NSCLC, Another Unique Never\u2010Smoker Predominant Molecular Subtype of NSCLC","volume":"15","author":"Lee A. 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