{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:25:59Z","timestamp":1765261559172,"version":"3.46.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260591"],"award-info":[{"award-number":["82260591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2023AAC05033"],"award-info":[{"award-number":["2023AAC05033"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The synchronous occurrence of epithelial\u2010derived gastric signet ring cell carcinoma and mesenchymal\u2010derived pulmonary fibrosarcoma in a single patient is extremely rare in clinical practice. Here, we report the case of a 23\u2010year\u2010old man who presented with hematemesis and melena for 6\u2009days. Gastroscopy revealed two irregular small ulcers in the upper\u2010middle segment of the gastric body.\n                    <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                    imaging demonstrated uneven thickening of the gastric wall along the greater curvature, with local ulcer formation, as well as a small nodule in the left lower lobe of the lung. The patient underwent thoracotomy, and postoperative pathology confirmed signet ring cell carcinoma in the stomach and fibrosarcoma in the lung. The coexisting tumor was diagnosed in one patient although it is unknown whether it is an accidental event or is caused by some underlying mechanism that makes him develop different malignancy in different organs simultaneously. This report serves to alert clinicians to this rare condition.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71037","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:57:50Z","timestamp":1761893870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous Occurrence of Gastric Signet Ring Cell Carcinoma and Pulmonary Fibrosarcoma in 23\u2010Year\u2010Old Male Youth"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-6250","authenticated-orcid":false,"given":"Meng","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Basic Medicine Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Ma","sequence":"additional","affiliation":[{"name":"The Second Department of Surgical Oncology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Department of Surgical Oncology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010019\u201000960\u2010w"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i40.11428"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010018\u20100868\u20100"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S188622"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201011096\u20103_7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj4784"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12282"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/1999\u2010123\u20100731\u2010DOPFOT"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2021.101900"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081940"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.5152\/turkjsurg.2017.3279"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896907302369"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa\u20102023\u20100009"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010019\u20101246\u20104"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms\/185326"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12399"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010020\u201001094\u20107"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.03.008"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2023.0079"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2022.100858"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184599"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16407"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02039"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28988"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.01.038"}],"container-title":["Clinical 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