{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:09:30Z","timestamp":1790240970753,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tetanus is a life\u2010threatening disease preventable by immunization through vaccines. In resource\u2010limited settings, its association with other acute infections should be managed cautiously. A 4\u2010year\u2010old unvaccinated male was referred from a nearby hospital for better management of severe malaria and probable enteric fever, after presenting there with febrile seizures, neck stiffness, and vomiting. Shortly after admission, he developed trismus, recurrent generalized paroxysmal muscle spasms, and opisthotonos. Given the clinical features and lack of antitetanic immunization, a diagnosis of tetanus and cerebral malaria was established, with probable bacterial meningitis as a relevant differential. Owing to the caregiver's financial constraints, no specific investigations were carried out. The patient was admitted to the intensive care unit (ICU) and empirically treated for all three likely diagnoses, with anti\u2010tetanus toxoid, antibiotics, and antimalarial. Despite limited supportive care, the patient's condition considerably improved within the first 48\u2009h in the ICU, and he spent 5 additional days in the hospital before being discharged.<\/jats:p>","DOI":"10.1002\/ccr3.71043","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T03:44:46Z","timestamp":1759117486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Generalized Tetanus Associated With Malaria and Probable Meningitis in a 4\u2010Year\u2010Old Patient: A Case Report in Limbe Regional Hospital, Cameroon"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8994-4504","authenticated-orcid":false,"given":"Christian Damien","family":"Tchuisseu Ngapjang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Health Sciences University of Buea  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fotso","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Limbe Regional Hospital, South\u2010West Region  Limbe Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Gobina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Health Sciences University of Buea  Buea Cameroon"},{"name":"Department of Anesthesiology and Intensive Care Medicine Buea Regional Hospital  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe Albert","family":"Lingo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Health Sciences University of Buea  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quincy\u2010Jones","family":"Shumbang Tchumukong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Health Sciences University of Buea  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertold Brecht","family":"Kouam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Health Sciences University of Buea  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Effila","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Health Sciences University of Buea  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelinda","family":"Berinyuy Nyuydzefon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Health Sciences University of Buea  Buea Cameroon"},{"name":"Department of Anesthesiology and Intensive Care Medicine Buea Regional Hospital  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verla","family":"Vincent Siysi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics, Faculty of Health Sciences University of Buea  Buea Cameroon"},{"name":"Department of Anesthesiology and Intensive Care Medicine Buea Regional Hospital  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5010073"},{"key":"e_1_2_13_3_1","unstructured":"CDC \u201cTetanus|Causes and Transmission|Lockjaw|CDC [Internet] \u201d(2016) http:\/\/www.cdc.gov\/tetanus\/about\/causes\u2010transmission.html."},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab013"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.3.292"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)33131-3"},{"key":"e_1_2_13_7_1","volume-title":"StatPearls [Internet]","author":"George E. 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