{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:12:42Z","timestamp":1790241162850,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Piperacillin sodium\/tazobactam sodium (PIP\u2010TAZ) is a commonly used antibiotic for various infections. While generally well\u2010tolerated, it has been associated with rare cases of neutropenia and thrombocytopenia. This case report highlights the potential for PIP\u2010TAZ to cause these adverse effects, emphasizing the importance of vigilant monitoring and timely intervention. A 79\u2010year\u2010old female with chronic renal failure and end\u2010stage renal disease developed neutropenia and thrombocytopenia during treatment with PIP\u2010TAZ for a suspected lung infection. Her neutrophil count plummeted from 11.17\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L to 0.37\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L, while her platelet count dropped from 282\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L to 4\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L. Despite interventions including platelet transfusions, the counts only normalized after discontinuing PIP\u2010TAZ.P2P4. The patient's clinical course and response to discontinuation of PIP\u2010TAZ suggest a likely causal relationship between the drug and her hematological abnormalities. Differential diagnoses, including severe infection, disseminated intravascular coagulation, and hematological malignancies, were ruled out through clinical examination and laboratory tests. The exact mechanism by which PIP\u2010TAZ causes neutropenia and thrombocytopenia remains unclear but may involve immune\u2010mediated reactions, direct drug toxicity, individual differences, and potential drug interactions in patients with renal impairment. Preventative measures include thorough pre\u2010treatment evaluation, close monitoring of complete blood counts, individualized medication regimens, and prompt discontinuation upon suspicion of adverse effects. This case report underscores the need for clinicians to be aware of the potential hematological adverse effects of PIP\u2010TAZ, particularly in patients with chronic diseases or renal insufficiency. Regular monitoring, prompt recognition, and timely intervention are crucial for ensuring patient safety and minimizing the risk of serious complications.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71062","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:31:30Z","timestamp":1760610690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Piperacillin Sodium and Tazobactam Sodium\u2010Induced Neutropenia and Thrombocytopenia: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-2380","authenticated-orcid":false,"given":"Hongyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, The Third Clinical Faculty of Guangxi University of Chinese Medicine  Liuzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaile","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, The Third Clinical Faculty of Guangxi University of Chinese Medicine  Liuzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, The Third Clinical Faculty of Guangxi University of Chinese Medicine  Liuzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, The Third Clinical Faculty of Guangxi University of Chinese Medicine  Liuzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, The Third Clinical Faculty of Guangxi University of Chinese Medicine  Liuzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02637-18"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac416"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231162434"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4212\/cjhp.3161"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu780"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2013.08.003"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730040-00002"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000001255"},{"issue":"7","key":"e_1_2_13_10_1","article-title":"Piperacillin\u2010Tazobactam Induced Rapid Severe Thrombocytopenia Without Known Exposure","volume":"14","author":"Bhaskarla A.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-020-01071-8"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/08971900211048140"},{"issue":"1","key":"e_1_2_13_13_1","first-page":"53","article-title":"Piperacillin\/Tazobactam Induced Myelosuppression","volume":"1","author":"Lee K. W.","year":"2009","journal-title":"Journal of Clinical Medicine Research"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-232944"},{"issue":"12","key":"e_1_2_13_15_1","article-title":"Zosyn\u2010Induced Rapid Thrombocytopenia in a Patient With End\u2010Stage Renal Disease and HIV: A Case Report","volume":"15","author":"Adhikari S.","year":"2023","journal-title":"Cureus"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:52:17Z","timestamp":1790239937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ccr3.71062"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71062","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71062"}}