{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:10:27Z","timestamp":1790241027336,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Haloperidol and other antipsychotics can cause buccolingual masticatory syndrome (BLMS), a rare but serious extrapyramidal disorder characterized by involuntary movements of the cheeks, jaws, and tongue. The author describes a 40\u2010year\u2010old man presenting with retrograde lingual movements, chewing difficulties, and speech impairment after 2\u2009years of haloperidol therapy for catatonic\u2010type schizophreniform disorder. Magnetic resonance imaging showed abnormal activity in the basal ganglia without structural lesions. Treatment with oral trihexyphenidyl hydrochloride, 5\u2009mg daily, resulted in symptom resolution within 24\u2009h. Haloperidol induces motor dysfunction by blocking dopamine D2 receptors in the basal ganglia. Haloperidol was discontinued, and the patient was transitioned to clozapine, a second\u2010generation antipsychotic with a lower risk of tardive dyskinesia. Clozapine was initiated at 12.5 mg daily and titrated to 50 mg daily over two weeks, following standard hematologic monitoring protocols. Early diagnosis and appropriate management, including medication adjustment and adjunctive therapy, are critical to optimizing outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.71083","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T06:52:59Z","timestamp":1759474379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Haloperidol Induced Orofacial Dyskinesia: Clinical Insights Into Buccolingual Masticatory Syndrome"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-9601","authenticated-orcid":false,"given":"Gudisa","family":"Bereda","sequence":"first","affiliation":[{"name":"Pharmacy Rift Valley University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","unstructured":"G.Bereda \u201cUncommon Buccolingual Masticatory Syndrome: Antipsychotic Medicine not Only Allows You to Live a Normal Life but It Also Increases the Risk of Physical Changes 09 January 2023 PREPRINT (Version 1) Available at Research Square\u201d https:\/\/doi.org\/10.21203\/rs.3.rs\u20102458355\/v1.","DOI":"10.21203\/rs.3.rs-2458355\/v1"},{"key":"e_1_2_14_3_1","unstructured":"M. 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