{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:11:08Z","timestamp":1790241068274,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Heterotopic pancreas (HP)\u2014defined as ectopic pancreatic tissue lacking vascular or ductal connections to the main organ\u2014represents an exceedingly rare anatomical variant in the gallbladder. This developmental anomaly warrants careful clinical attention due to its potential surgical implications. We report a case of a 38\u2010year\u2010old female who presented to the emergency department with progressive abdominal pain, nausea, and vomiting. Ultrasonographic evaluation revealed a solitary 15\u2010mm gallstone without evidence of gallbladder wall inflammation. Following laparoscopic cholecystectomy, histological examination of the 7.5\u2009cm\u2009\u00d7\u20093\u2009cm specimen demonstrated acute\u2010on\u2010chronic cholecystitis with localized cholesterolosis. Microscopic evaluation revealed heterotopic pancreatic tissue beneath the gallbladder fundus serosa. The tissue displayed complete pancreatic architecture\u2014including acini, ducts, and islets of Langerhans\u2014without evidence of malignancy or dysplasia. The patient experienced an uncomplicated postoperative course, with complete symptom resolution during follow\u2010up. This case emphasizes the importance of thorough histopathological examination in identifying rare anatomical variants and contributes to the limited literature on gallbladder HP. While typically asymptomatic, recognition of HP remains crucial for appropriate surgical planning and patient management.<\/jats:p>","DOI":"10.1002\/ccr3.71091","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T08:39:06Z","timestamp":1759307946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterotopic Pancreas in the Gallbladder: An Incidental Finding Following Laparoscopic Cholecystectomy in a Patient With Cholelithiasis"],"prefix":"10.1002","volume":"13","author":[{"given":"Aram","family":"Farhoudian","sequence":"first","affiliation":[{"name":"School of Medicine Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2826-5572","authenticated-orcid":false,"given":"Sepideh","family":"Hadimaleki","sequence":"additional","affiliation":[{"name":"Department of Pathology Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9171-5997","authenticated-orcid":false,"given":"Bahareh","family":"Mehramouz","sequence":"additional","affiliation":[{"name":"Department of Pathology Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-1683","authenticated-orcid":false,"given":"Amirreza","family":"Khalaji","sequence":"additional","affiliation":[{"name":"Immunology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"issue":"3","key":"e_1_2_14_2_1","article-title":"Pancreatic Heterotopia at the Gastroesophageal Junction: A Case Report and Review of the Literature","volume":"15","author":"Kumar V.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2010.01.005"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2012.45.3.194"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912010000600007"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.31486\/toj.23.0120"},{"issue":"6","key":"e_1_2_14_7_1","first-page":"1297","article-title":"The Role of Manganese Superoxide Dismutase in the Growth of Pancreatic Adenocarcinoma","volume":"63","author":"Cullen J. 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