{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:11:33Z","timestamp":1790241093514,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tumor Necrosis Factor\u2010alpha (TNF\u2010\u03b1) inhibitors have been successfully used to treat rheumatoid arthritis (RA), psoriatic and ankylosing arthritis, and inflammatory bowel disease. While these inhibitors effectively decrease the inflammatory activity of immune\u2010related disorders, they have been associated with central nervous system (CNS) and peripheral demyelination. In this study, we report a 44\u2010year\u2010old female patient with RA who developed neurological symptoms after a course of infliximab therapy due to tumefactive demyelinating lesions (TDLs). Imaging findings led to discontinuation of the drug and treatment with corticosteroids, resulting in clinical improvement. This case underscores the importance of monitoring neurological side effects during TNF\u2010\u03b1 therapy and early intervention when symptoms occur. Tumor necrosis factor\u2010alpha inhibitors, such as infliximab, can unmask or induce demyelinating lesions, even in patients without prior multiple sclerosis. Prompt MRI evaluation and infliximab discontinuation, followed by corticosteroids, can lead to clinical improvement. Neurological assessment is recommended before initiating TNF\u2010\u03b1 inhibitors, especially in patients with risk factors for demyelination.<\/jats:p>","DOI":"10.1002\/ccr3.71144","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:34:34Z","timestamp":1760009674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tumefactive Demyelinating Lesion Induced by Infliximab in a Patient With Rheumatoid Arthritis: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-8384","authenticated-orcid":false,"given":"Shahla Mohammed Saeed","family":"Rasul","sequence":"first","affiliation":[{"name":"Branch of Clinical Sciences, College of Medicine University of Sulaimani  Sulaimaniyah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9069-3692","authenticated-orcid":false,"given":"Zana Abdulrahman","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Branch of Clinical Sciences, College of Medicine University of Sulaimani  Sulaimaniyah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1354-9768","authenticated-orcid":false,"given":"Aran Asaad","family":"Adiban","sequence":"additional","affiliation":[{"name":"Branch of Clinical Sciences, College of Medicine University of Sulaimani  Sulaimaniyah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6907-9896","authenticated-orcid":false,"given":"Yahya Jawad","family":"Kadhm","sequence":"additional","affiliation":[{"name":"Branch of Clinical Sciences, College of Medicine University of Sulaimani  Sulaimaniyah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2021.10.003"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030768"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.690118"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.08.014"},{"key":"e_1_2_13_6_1","first-page":"1","article-title":"How Does Infliximab Work in Rheumatoid Arthritis?","volume":"4","author":"Maini R. 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