{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:11:40Z","timestamp":1790241100055,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Platelet\u2010rich plasma (PRP) therapy, while widely utilized for its favorable safety profile, carries a recognized risk of catastrophic, irreversible vision loss, traditionally attributed to iatrogenic vascular embolization following facial injections. We present the first documented case of\n                    <jats:italic>reversible<\/jats:italic>\n                    , subacute vision loss following PRP injections to the\n                    <jats:italic>scalp<\/jats:italic>\n                    , a finding that fundamentally challenges this established paradigm. A 22\u2010year\u2010old female presented with unilateral central scotomas one month post\u2010treatment, with investigations revealing macular edema and an incidental, non\u2010compressive pituitary microadenoma. In contrast to direct embolic occlusion, we postulate a novel pathophysiological mechanism: a systemic surge of PRP\u2010derived growth factors (e.g., VEGF, PDGF) triggered a transient, steroid\u2010responsive inflammatory or microvascular event in a pre\u2010sensitized neurovascular environment. The patient achieved complete visual recovery following high\u2010dose corticosteroid therapy, supporting an inflammatory etiology. This case serves as an unequivocal clinical directive that the risk of severe ocular complications from PRP is not confined to facial injections and can manifest systemically. It is imperative that the paradigm of PRP\u2010related risk be expanded and informed consent protocols revised to reflect the potential for inflammatory and microvascular sequelae, irrespective of the injection site.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71191","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:33:36Z","timestamp":1759898016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reversible Vision Loss With Pituitary Microadenoma Following\n                    <scp>PRP<\/scp>\n                    Injection for Hair Growth: A Rare Case Report and a Mini\u2010Review of the Literature"],"prefix":"10.1002","volume":"13","author":[{"given":"Fazeela","family":"Bibi","sequence":"first","affiliation":[{"name":"Jinnah Medical and Dental College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4375-6632","authenticated-orcid":false,"given":"Ahmad","family":"Sanan","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Hamza","sequence":"additional","affiliation":[{"name":"Saidu Medical College  Swat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7700-8269","authenticated-orcid":false,"given":"Muhammad","family":"Talha Rehman Sherani","sequence":"additional","affiliation":[{"name":"Sandeman Provincial Hospital  Quetta Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Salahuddin","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar 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