{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:13:13Z","timestamp":1790241193350,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cutaneous leishmaniasis (CL) remains a therapeutic challenge in endemic regions, with 600,000\u20131 million new cases annually facing limited treatment options. We present a case series evaluating an innovative topical combination therapy for acute\u2010phase CL in Shiraz, Iran. Three treatment\u2010na\u00efve patients (45\u2010year\u2010old female with forearm lesions, 18\u2010year\u2010old male with foot involvement, and 52\u2010year\u2010old female with hand lesions) received daily applications of a novel solution containing ciprofloxacin, ketoconazole, and metronidazole for 30\u2009days, followed by alpha hydroxy acid for scar rehabilitation. Remarkably, all patients demonstrated complete lesion resolution and significant cosmetic improvement without treatment\u2010related adverse events. This well\u2010tolerated regimen offers several advantages over conventional systemic antimonials, including reduced toxicity, improved accessibility, and simplified administration. Our findings support the growing body of evidence for topical CL treatments, offering a potentially safer, more accessible option that warrants further clinical investigation in endemic regions. This study highlights the importance of developing targeted therapies that consider both clinical efficacy and practical implementation challenges in resource\u2010limited settings.<\/jats:p>","DOI":"10.1002\/ccr3.71211","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:03:13Z","timestamp":1759899793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complete Resolution of Cutaneous Leishmaniasis With a Novel Topical Combination Therapy: A Case Series"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3684-3988","authenticated-orcid":false,"given":"Hoda","family":"Haghshenas","sequence":"first","affiliation":[{"name":"Faculty of Medicine Jahrom University of Medical Sciences (JUMS)  Jahrom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aref","family":"Ghanaatpisheh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Jahrom University of Medical Sciences (JUMS)  Jahrom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-7807","authenticated-orcid":false,"given":"Mohammad","family":"Darayesh","sequence":"additional","affiliation":[{"name":"Deputy of Education, Department of Dermatology Jahrom University of Medical Sciences  Jahrom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Entezar Almahdi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.02.007"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid3007.231404"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13098"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009099"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.03.018"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2012.701204"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-024-06381-8"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0012127"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:55:26Z","timestamp":1790240126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ccr3.71211"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71211","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.174826640.00345095\/v1","asserted-by":"object"}]},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71211"}}