{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:14:36Z","timestamp":1790241276236,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hydroxychloroquine (HCQ) is a common treatment for recurrent implantation failure (RIF), which may be associated with diverse side effects. We report a case of a 36\u2010year\u2010old RIF3 pregnant female through in\u00a0vitro fertilization (IVF) presented to the emergency department with painful, itchy, macular, erythematous, blanchable, and exfoliative skin lesions distributed on the face, upper trunk, and upper limbs. She had been prescribed HCQ about 10\u2009days before embryo transfer for her RIF history. With suspicion of Stevens\u2013Johnson syndrome\/Toxic epidermal necrolysis (TEN), HCQ was discontinued, and intravenous immunoglobulins (IVIg), triamcinolone, chlorpheniramine, and body lotion were administered. Considering more than 30% of the total body surface area involvement, within 3\u2009days of treatment, and with favorable improvements, the diagnosis of TEN was confirmed. With the rising popularity of HCQ in immune\u2010related conditions, it is essential to highlight the significance of continuous monitoring for uncommon adverse reactions. The need for vigilance becomes particularly critical in patients requiring immediate intervention to prevent irreversible consequences.<\/jats:p>","DOI":"10.1002\/ccr3.71226","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:16:07Z","timestamp":1760404567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Toxic Epidermal Necrolysis and Recurrent Implantation Failure: Unveiling a Rare Phenomenon During Pregnancy"],"prefix":"10.1002","volume":"13","author":[{"given":"Hatav","family":"Ghasemi Tehrani","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Infertility School of Medicine, Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Zakerinasab","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Khalili Geshnigani","sequence":"additional","affiliation":[{"name":"Students Research Committee Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-8759","authenticated-orcid":false,"given":"Rahem","family":"Rahmati","sequence":"additional","affiliation":[{"name":"Students Research Committee Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Zamani Dehkordi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Infertility School of Medicine, Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.029"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.25122\/jml-2022-0095"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15908"},{"issue":"3","key":"e_1_2_14_5_1","article-title":"Extended Letrozole Treatment for Ovulation Induction and Clinical Pregnancy in Conventional Treatment\u2010Resistant Polycystic Ovary Syndrome Patients: A Prospective Parallel Randomized Clinical Trial","volume":"2024","author":"Mehrabian F.","year":"2024","journal-title":"Journal of Obstetrics and Gynecology of India"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del305"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000165776"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:29:3:327"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.10.062"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12338"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00946.x"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.02.004"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306071872"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.024"},{"issue":"3","key":"e_1_2_14_15_1","first-page":"212","article-title":"Prolonged Pustular Eruption From Hydroxychloroquine: An Unusual Case of Acute Generalized Exanthematous Pustulosis","volume":"97","author":"Pearson K. 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