{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:13:04Z","timestamp":1790241184453,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Characterized by early lymphatic metastasis, aggressive growth, and a weak prognosis, small cell esophageal carcinoma (SCEC) lacks established standard treatment guidelines. This report discusses SCEC by case study and includes a relevant literature review. A 66\u2010year\u2010old male was diagnosed with SCEC through computed tomography (CT), esophagoscopy, and pathological examination, presenting with multiple mediastinal lymph node metastases at diagnosis. The patient underwent chemotherapy, receiving 120\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    etoposide (D 1\u20133) and 60\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    cisplatin (D 1) every 4\u2009weeks. Dysphagia improved significantly and the mediastinal lymph node size was reduced after 4 cycles. However, lymph node enlargement recurred after 8 cycles, and the patient could no longer tolerate chemotherapy. Subsequently, the patient was arranged to be administered radiotherapy (54\u2009Gy). The patient has completed 10 radiotherapy sessions and survived 8 months post\u2010diagnosis, continuing treatment. Early initiation of chemoradiotherapy is recommended for patients with locally advanced SCEC.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71235","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:42:53Z","timestamp":1760330573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Esophageal Small Cell Neuroendocrine Carcinoma: A Case Report With a Review of Presentation, Treatment, and Survival"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9578-7154","authenticated-orcid":false,"given":"Zi\u2010Han","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiac Surgery The People's Hospital of QianNan  DuYun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Hao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiac Surgery The People's Hospital of QianNan  DuYun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua\u2010Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiac Surgery The People's Hospital of QianNan  DuYun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-3334"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i30.9011"},{"key":"e_1_2_11_4_1","first-page":"EC04","article-title":"Primary Small Cell Carcinoma of the Esophagus\u2014An Eight Year Retrospective Study","volume":"9","author":"Nayal B.","year":"2015","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5615009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2023.01.002"},{"key":"e_1_2_11_7_1","first-page":"437","article-title":"Multimodality Therapy Is Recommended for Limited\u2010Stage Combined Small Cell Esophageal Carcinoma","volume":"8","author":"Wang H.\u2010H.","year":"2015","journal-title":"OncoTargets and Therapy"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.3.11368"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.01.008"},{"key":"e_1_2_11_10_1","first-page":"1","article-title":"Treatment and Survival Outcomes of Small Cell Carcinoma of the Esophagus: An Analysis of the National Cancer Data Base","volume":"30","author":"Wong A. 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