{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:11:30Z","timestamp":1790241090331,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ethmocephaly is the most severe form of holoprosencephaly, which results from incomplete cleavage of the forebrain during embryogenesis. It is incompatible with life. Here we reported a case of ethmocephaly in a clomiphene citrate induced pregnancy in a 32\u2010year\u2010old, gravida 6 woman, at a gestational age of 23\u2009weeks. Upon ultrasound scanning, there were brain abnormalities, like a single dilated ventricle, absent falx cerebri, and facial profile abnormalities like proboscis. After delivery, on physical examination of the newborn, we found ocular hypotelorism, a 5\u2009cm midline proboscis located above the eyes, and absent nasal structures. The patient had used clomiphene for two cycles prior to conception, with no other notable medical history. In conclusion, ethmocephaly is a severe and typically fatal condition requiring early prenatal detection for better planning. While there is no clear link between clomiphene use and holoprosencephaly, further research is needed to explore any potential risks and guide clinical practice.<\/jats:p>","DOI":"10.1002\/ccr3.71254","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T04:19:03Z","timestamp":1760069943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Ethmocephaly in a Clomiphene Citrate Induced Pregnancy: A Case Report and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3808-7750","authenticated-orcid":false,"given":"Musie","family":"Negasi Gebreslase","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Aksum University College of Health Science  Aksum Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1897-9072","authenticated-orcid":false,"given":"Birhanu Kassie","family":"Reta","sequence":"additional","affiliation":[{"name":"Department of Pathology Aksum University College of Health Science  Aksum Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-2447","authenticated-orcid":false,"given":"Awol","family":"Yeman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mekelle University College of Health Science  Mekelle Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4988-2282","authenticated-orcid":false,"given":"Haftom","family":"Guesh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aksum University College of Health Science  Aksum Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3314-2088","authenticated-orcid":false,"given":"Million","family":"Abraha","sequence":"additional","affiliation":[{"name":"Department of Surgery Aksum University College of Health Science  Aksum Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6070-7608","authenticated-orcid":false,"given":"Dawit","family":"Negash","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aksum University College of Health Science  Aksum Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0248-7766","authenticated-orcid":false,"given":"Awash","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Radiology Aksum University College of Health Science  Aksum Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4936-1052","authenticated-orcid":false,"given":"Yordanos","family":"Birhane","sequence":"additional","affiliation":[{"name":"School of Medicine Aksum University College of Health Science  Aksum Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Holoprosencephaly Overview Goal 1 Goal 2 Goal 3 Goal 4 Inform Genetic Counseling of Family Members of an Individual With Holoprosencephaly","author":"Tekendo Ngongang C.","year":"2000"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-07416-5.50020-4"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRN.S444777"},{"key":"e_1_2_14_5_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/B978-0-7020-6956-7.00028-2","article-title":"Sonography of the Fetal Central Nervous System","volume":"14","author":"De Catte L.","year":"2020","journal-title":"Fetal Medicine: Basic Science and Clinical Practice"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3291.ijcp20240351"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30250"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(83)80185\u20101"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400206"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.018"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420490203"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.03.018"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280110"},{"issue":"4","key":"e_1_2_14_15_1","first-page":"535","article-title":"Holoprosencephaly in Clomiphene\u2010Induced Pregnancy: A Possible Association? 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