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The patient exhibited complete right\u2010sided limb paralysis following trauma, with full muscle strength recovery after therapy. Serial diffusion tensor imaging evaluations revealed persistently reduced fractional anisotropy values in the left corticospinal tract (CST.L) below the normal range posttreatment, indicating a structure\u2013function decoupling phenomenon. Despite incomplete restoration of structural integrity in CST.L, significant motor function improvement was observed. The findings suggest that meridian\u2010sinew therapy may promote motor recovery through activation of compensatory networks involving non\u2010CST pathways. This investigation provides neuroimaging evidence supporting the therapeutic efficacy of meridian\u2010sinew therapy in TBI\u2010induced hemiplegia and offers novel insights into potential mechanisms of action.<\/jats:p>","DOI":"10.1002\/ccr3.71296","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:09:06Z","timestamp":1761109746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural\u2010Functional Dissociation in TBI Hemiplegia: Meridian\u2010Sinew Therapy Promotes Motor Recovery Despite Corticospinal Tract Damage\u2014A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8022-2948","authenticated-orcid":false,"given":"Juyue","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital, Shantou University Medical College  Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital, Shantou University Medical College  Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengbiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital, Shantou University Medical College  Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital, Shantou University Medical College  Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Wu","sequence":"additional","affiliation":[{"name":"Shantou Longhu District Jinrou Traditional Chinese Medicine Research Institute  Shantou China"},{"name":"Beijing Jinrou Traditional Chinese Medicine Research Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital, Shantou University Medical College  Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17352"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2011-0710"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283314b11"},{"issue":"10","key":"e_1_2_12_6_1","article-title":"Perks of Early Physical Therapy Rehabilitation for a Patient With Diffuse Axonal Injury","volume":"14","author":"Lalwani S. 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