{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:33:59Z","timestamp":1766399639403,"version":"3.48.0"},"reference-count":8,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Aneurysms of pulmonary arteries and aorta are rare, typically caused by infections, congenital heart defects, vascular abnormalities, or medical interventions. This report presents an unusual case of a 72\u2010year\u2010old man with a history of smoking, hypertension, and emphysema, who was found to have a large pulmonary artery aneurysm (63.5\u2009mm) and aortic root dilation (46\u2009mm). Despite normal inflammatory markers and no typical giant cell arteritis (GCA) symptoms, histopathology following surgical repair revealed focal GCA as the underlying cause. The patient underwent successful valve\u2010sparing root replacement and was subsequently treated with prednisone and tocilizumab, showing clinical improvement. This case underscores the existence of a rare GCA phenotype\u2014extracranial GCA\u2014that affects major arteries without cranial involvement and often lacks classic symptoms. Extracranial GCA carries serious risks, including dissection and rupture, particularly in hypertensive individuals. The continuous inflammation in GCA leads to medial degeneration and aneurysm formation. Advancements in imaging have improved early detection and intervention, though the rarity of this condition limits large\u2010scale studies. As a result, diagnosis and treatment rely heavily on case reports. Glucocorticoids and immunomodulators remain the mainstay of therapy, but more research is needed to optimize management for this atypical GCA presentation.<\/jats:p>","DOI":"10.1002\/ccr3.71311","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:35:38Z","timestamp":1764214538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Giant Cell Arteritis Affecting Two Giants: Pulmonary and Root of Aorta Aneurysm"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7444-8966","authenticated-orcid":false,"given":"Gajendra","family":"Acharya","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Tidalhealth Peninsula Regional  Salisbury Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiza","family":"Baloch","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Tidalhealth Peninsula Regional  Salisbury Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Masuta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Tidalhealth Peninsula Regional  Salisbury Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-3098","authenticated-orcid":false,"given":"Rohit","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tidalhealth Peninsula Regional  Salisbury Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kimelheim","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Tidalhealth Peninsula Regional  Salisbury Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabal","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kathmandu University Hospital  Dhulikhel Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030495"},{"key":"e_1_2_13_3_1","first-page":"506","article-title":"The Spectrum of Giant Cell Arteritis and Polymyalgia Rheumatica: Revisiting the Concept of the Disease","volume":"56","author":"Dejaco C.","year":"2017","journal-title":"Rheumatology (Oxford, England)"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex424"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.40.2.156"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt411"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2023.10.038"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613849"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24632"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:29:56Z","timestamp":1766399396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ccr3.71311"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71311","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"2025-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71311"}}