{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:12:00Z","timestamp":1790241120502,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Clinically manifest porphyria cutanea tarda (PCT) is a rare condition in childhood; however, several cases have been reported in the literature and at our centre. Porphyria Center Sweden is a national knowledge centre, and since 1987, we have diagnosed approximately 1400 new cases of manifest PCT, of which only five have been children. All children have been identified as heterozygous carriers of a pathogenic\n                    <jats:italic>UROD<\/jats:italic>\n                    gene variant and homozygous for hemochromatosis. In our experience, the diagnosis of children with PCT has been delayed, even in the presence of cutaneous symptoms, without known family history. In this case report, and in another child from our centre, the disease has been suspected due to reddish discolored urine in the absence of cutaneous symptoms. In these two cases, the mothers associated the beetroot red urine with known cases of PCT in the family history. The remaining three cases documented in this report were diagnosed based on cutaneous symptoms.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71323","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:17:46Z","timestamp":1760595466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Beetroot Colored Urine in a Three\u2010Year\u2010Old Child: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-2801","authenticated-orcid":false,"given":"Pauline","family":"Harper","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics, Centre for Inherited Metabolic Diseases, Porphyria Centre Sweden, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl\u2010Johan","family":"T\u00f6rnhage","sequence":"additional","affiliation":[{"name":"Institute of Clinical Science, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Pediatrics Skaraborg's Hospital  Skovde Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Sardh","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Centre for Inherited Metabolic Diseases, Porphyria Centre Sweden, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Endocrinology, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.04.008"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.01.004"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1005313024076"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2002.04591.x"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.12.3179"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102796.2004.01309.x"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655100448338"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190\u20109622(92)70277\u2010m"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(98)70464\u20105"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.284967"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.020"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5352.272"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295407"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1998.tb00014.x"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(85)90287\u20109"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954\u20106820.1970.tb08003.x"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954\u20106820.1968.tb02443.x"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700547104"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1957.01550180015004"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510240006002"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0510071"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250359"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101470.1992.tb00634.x"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010018\u20104669\u20102"},{"issue":"2","key":"e_1_2_15_26_1","first-page":"95","article-title":"A Case\u2010Based Review of Iron Overload With an Emphasis on Porphyria Cutanea Tarda, Hepatitis C, C282Y Heterozygosity, and Coronary Artery Disease","volume":"37","author":"Hashemi L.","year":"2020","journal-title":"Federal Practitioner"},{"key":"e_1_2_15_27_1","unstructured":"S.Rudnick J.Phillips H.Bonkovsky andPorphyrias Consortium of the Rare Diseases Clinical Research N \u201cFamilial Porphyria Cutanea Tarda \u201dinGeneReviews\u00ae ed. 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