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The patient, a 79\u2010year\u2010old male with a 10\u2010year history of recurrent submandibular symptoms, was found to have both ductal and intraglandular stones alongside non\u2010uniform glandular enlargement. Post\u2010surgical analysis confirmed CXPA. The patient remained disease\u2010free with good functional outcomes at 24\u2010month follow\u2010up. This case provides valuable insights, suggesting a potential pathophysiological link between the chronic inflammation associated with long\u2010standing lithiasis and the malignant transformation leading to CXPA. It underscores the importance of comprehensive diagnostic evaluation for chronic or atypical submandibular gland conditions to rule out concurrent malignancy.<\/jats:p>","DOI":"10.1002\/ccr3.71327","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:09:39Z","timestamp":1761894579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Carcinoma Ex\u2010Pleomorphic Adenoma With Concurrent Submandibular Gland Lithiasis\u2014A Rare Association With Potential Pathophysiological Implications"],"prefix":"10.1002","volume":"13","author":[{"given":"Huiquan","family":"Lou","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgery Department The First People's Hospital of Yunnan Province\/The Affiliated Hospital of Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Xia","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department The First People's Hospital of Yunnan Province\/The Affiliated Hospital of Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengjie","family":"Shao","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department The First People's Hospital of Yunnan Province\/The Affiliated Hospital of Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department The First People's Hospital of Yunnan Province\/The Affiliated Hospital of Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Deng","sequence":"additional","affiliation":[{"name":"Pathology Department The First People's Hospital of Yunnan Province\/The Affiliated Hospital of Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Yan'an Hospital of Kunming City, The Affiliated Yan'an Hospital of Kunming Medical University  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-6267","authenticated-orcid":false,"given":"Zengzheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The First People's Hospital of Yunnan Province\/The Affiliated Hospital of Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01704-3"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visj.2025.102195"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0281-z"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000146"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6657(07)70507-3"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.10.1277"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.106052"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omsc.2020.100166"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14168"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-012-0024-3"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104494"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-01071-x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63763-9"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.24.3588"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43163-024-00575-8"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.25000"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0454-z"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.519"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13070796"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2023.942604"},{"issue":"1","key":"e_1_2_13_22_1","article-title":"CD117\/c\u2010Kit in Cancer Stem Cell\u2010Mediated Progression and Therapeutic Resistance","volume":"6","author":"Foster B. 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