{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:12:57Z","timestamp":1790241177054,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Necrotizing fasciitis (NF) of the eyelid is an extremely rare but severe complication of varicella zoster virus (VZV) infection in children. We present a case of an 8\u2010year\u2010old girl who developed necrotizing fasciitis of the left eyelid following varicella infection. The patient initially presented with fever, vesicular rashes, and swelling of the left peri\u2010orbital region. She was treated with oral acyclovir (400\u2009mg five times daily for 7\u2009days) and prednisolone (10\u2009mg daily for 5\u2009days) at a local medical store. Due to worsening symptoms, she was admitted to our center where intravenous antibiotics\u2014Meropenem (40\u2009mg\/kg\/dose every 8\u2009h) and Vancomycin (15\u2009mg\/kg\/dose every 6\u2009h)\u2014were administered for 21\u2009days, followed by oral levofloxacin (250\u2009mg once daily for 2\u2009weeks). Surgical debridement of necrotic tissue was performed. Cultures revealed Coagulase\u2010negative Staphylococcus, Enterococcus, and later\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The patient responded well to treatment and showed healthy healing in follow\u2010up. This case emphasizes the importance of early surgical intervention, aggressive antibiotic therapy, and multidisciplinary care in managing rare but severe complications like periorbital necrotizing fasciitis secondary to varicella. Key clinical findings included progressive periorbital necrosis, culture results, and favorable response to combined medical and surgical therapy.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71334","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:38:28Z","timestamp":1761035908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Necrotizing Fasciitis of Eyelid in Children: A Rare Complication of Varicella Infection"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1902-7661","authenticated-orcid":false,"given":"Govinda","family":"Bhandari","sequence":"first","affiliation":[{"name":"Institute of Medicine Maharajgunj Medical Campus  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himal","family":"Acharya","sequence":"additional","affiliation":[{"name":"Institute of Medicine Maharajgunj Medical Campus  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Paudyal","sequence":"additional","affiliation":[{"name":"B.P Koirala Lions Centre for Opthalmic Studies  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_65_20"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.124959.2"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0163\u20104453(98)80154\u20100"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.4.698"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198905000-00044"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199607000-00015"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u2010620X.149874"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102018\u2010226363"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5230.944"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/IMCRJ.S421248"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/206152"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2017-207366.2"},{"key":"e_1_2_14_14_1","volume-title":"Textbook of Surgery: The Biological Basis of Modern Surgical Practice","author":"Sabiston D. C.","year":"1986"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:55:23Z","timestamp":1790240123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ccr3.71334"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71334","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.173607914.42276949\/v1","asserted-by":"object"}]},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71334"}}