{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:57:05Z","timestamp":1781715425177,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary presacral clear cell carcinoma (CCC) of M\u00fcllerian origin is extremely rare. Malignant transformation of endometriosis is a known phenomenon, though typically involving the ovaries or pelvic peritoneum. Retroperitoneal presentation, especially decades after definitive surgery, is exceedingly uncommon. A 60\u2010year\u2010old woman presented with a large retroperitoneal\/presacral pelvic mass leading to hydronephrosis, 20\u2009years after total abdominal hysterectomy and bilateral salpingo\u2010oophorectomy for endometriosis. MRI showed a cystic\u2010solid mass with mural nodularity. Surgical exploration revealed dense retroperitoneal adhesions with involvement of the rectosigmoid and the appendix. En bloc resection was performed in posterior exenterative fashion. Histopathology confirmed clear cell carcinoma arising from endometriotic foci, fulfilling Sampson's criteria. Postoperative management included adjuvant paclitaxel\u2010carboplatin chemotherapy. The patient recovered uneventfully and was scheduled for ileostomy reversal. This case illustrates the potential late malignant transformation of endometriosis into M\u00fcllerian CCC even decades after hysterectomy and oophorectomy. Endometriosis\u2010associated carcinoma should be considered in the differential diagnosis of retroperitoneal pelvic masses, particularly in women with prior endometriosis.<\/jats:p>","DOI":"10.1002\/ccr3.71335","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:11:04Z","timestamp":1762506664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Presacral Clear Cell Carcinoma of M\u00fcllerian Origin 20\u2009Years After Hysterectomy and Bilateral Salpingo\u2010Oophorectomy: A Case Report and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-6772","authenticated-orcid":false,"given":"Alaa","family":"Elzarka","sequence":"first","affiliation":[{"name":"Department of Gynaecology Oncology, Churchill Hospital Oxford University Hospitals National Health Service (NHS) Foundation Trust  Oxford UK"},{"name":"Gynaecology Oncology Unit, Department of Obstetrics and Gynaecology Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2831-2134","authenticated-orcid":false,"given":"Jacopo","family":"Conforti","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology, Churchill Hospital Oxford University Hospitals National Health Service (NHS) Foundation Trust  Oxford UK"},{"name":"Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina Ioana","family":"Nistor","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology, Churchill Hospital Oxford University Hospitals National Health Service (NHS) Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Awaly","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology, Churchill Hospital Oxford University Hospitals National Health Service (NHS) Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zouridis","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology, Churchill Hospital Oxford University Hospitals National Health Service (NHS) Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Tak\u2010kwan","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Oxford University Hospitals NHS Foundation Trust  Oxford United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology Oxford University Hospitals NHS Foundation Trust  Oxford United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Damato","sequence":"additional","affiliation":[{"name":"Department of Histopathology Oxford University Hospitals  Oxford United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunanda","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Histopathology Oxford University Hospitals  Oxford United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-5321","authenticated-orcid":false,"given":"Hooman Soleymani","family":"majd","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology, Churchill Hospital Oxford University Hospitals National Health Service (NHS) Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184614"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.06.033"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.10.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010014\u20100311\u2010x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.05.2009.1829"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/reports4030029"},{"key":"e_1_2_12_8_1","unstructured":"\u201cRetroperitoneal Tumours: Review of Management | The Annals of the Royal College of Surgeons of England \u201d accessed August 17 2025 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