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This case describes its occurrence following misoprostol administration in a highly vulnerable patient with sepsis, preeclampsia, and intrauterine fetal demise. While a temporal association was observed, causation cannot be definitively established. This report highlights the importance of vigilant monitoring and readiness for advanced respiratory support when using uterotonics in high\u2010risk, destabilized patients. It is crucial to emphasize that misoprostol remains a safe and lifesaving medication for the vast majority of obstetric patients, and this unique case should not deter its essential use.<\/jats:p>","DOI":"10.1002\/ccr3.71377","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:21:54Z","timestamp":1761808914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Perfect Storm: Pulmonary Edema Following Misoprostol Administration in the Midst of Sepsis, Pneumonia, and Retained Pregnancy: A Rare Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7147-0456","authenticated-orcid":false,"given":"Rahul Kumar","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Birat Medical College Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalit Kumar","family":"Rajbanshi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Birat Medical College Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Poudel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Birat Medical College Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumud","family":"Pyakurel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Birat Medical College Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prajwal","family":"Bista","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Birat Medical College Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"S160","article-title":"Misoprostol: Pharmacokinetic Profiles, Effects on the Uterus and Side\u2010Effects","volume":"99","author":"Tang O. 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