{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:26:06Z","timestamp":1765261566240,"version":"3.46.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) is a common hematological malignancy, and some patients may present with autoimmune hemolytic anemia (AIHA). However, the coexistence of DLBCL and paroxysmal nocturnal hemoglobinuria (PNH) is rare. PNH patients may develop myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), but lymphomas are rarely seen. Here, we focus on a 46\u2010year\u2010old female patient afflicted with PNH for 3\u2009years before being diagnosed with DLBCL. Different from DLBCL accompanied by AIHA, this case did not benefit from the R\u2010CHOP regimen. This case demonstrates that PNH can coexist with malignant lymphoma, which is a rare finding. It also enhances our understanding of the clinical management of DLBCL coexisting with PNH.<\/jats:p>","DOI":"10.1002\/ccr3.71394","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T04:16:17Z","timestamp":1763612177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse Large B\u2010Cell Lymphoma Combined With Paroxysmal Nocturnal Hemoglobinuria: A Rare Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3682-6458","authenticated-orcid":false,"given":"Zhen zhen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da lin","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Immunology Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An hua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Shandong Second Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201002\u2010522128"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000940"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003812"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.09.006"},{"issue":"2","key":"e_1_2_13_6_1","first-page":"134","article-title":"Long\u2010Term Remission of Paroxysmal Nocturnal Hemoglobinuria Following Chemoimmunotherapy for Non\u2010Hodgkin Lymphoma","volume":"10","author":"Lai S.","year":"2012","journal-title":"Clinical Advances in Hematology & 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